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Synthesis of Potential Mescaline Antagonists

F. Jun. Desantis, Karl A. Nieforth

Journal of Pharmaceutical Sciences October 1, 1976 DOI: 10.1002/jps.2600651016 (opens in new tab)

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AI-extracted from the abstract
Characteristics Laboratory experiment Peer reviewed
Interventions 1-[2-(3 4 5-Trimethoxyphenyl)ethyl]-3-pyrroline 2-(3 5-trimethoxybenzyl)-1 2 3 6-tetrahydropyridine N-n-propylmescaline N-cyclopropylmethylmescaline N-allylmescaline
Topics Mescaline
Keywords Stereochemistry Pharmacology
Citations 4
Key findings The synthesized compounds were evaluated for their ability to antagonize mescaline-induced disruption of swim behavior, and the results are presented.

Abstract

1-[2-(3,4,5-Trimethoxyphenyl)ethyl]-3-pyrroline, 2-(3,4,5-trimethoxybenzyl)-1,2,3,6-tetrahydropyridine, N-n-propylmescaline, N-cyclopropylmethylmescaline, and N-allylmescaline were synthesized as potential mescaline antagonists. The ability of these compounds to antagonize mescaline-induced disruption of swim behavior is also given.

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