Synthesis of Potential Mescaline Antagonists
F. Jun. Desantis, Karl A. Nieforth
Journal of Pharmaceutical Sciences October 1, 1976 DOI: 10.1002/jps.2600651016 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractSeveral chemical compounds related to mescaline were synthesized with the aim of blocking mescaline's effects. The substances included 1-[2-(3,4,5-Trimethoxyphenyl)ethyl]-3-pyrroline, 2-(3,4,5-trimethoxybenzyl)-1,2,3,6-tetrahydropyridine, N-n-propylmescaline, N-cyclopropylmethylmescaline, and N-allylmescaline. Their ability to counteract the disruption of swimming behavior caused by mescaline was tested and reported.
Study at a glance
| Characteristics | Laboratory experiment Peer reviewed |
|---|---|
| Interventions | 1-[2-(3 4 5-Trimethoxyphenyl)ethyl]-3-pyrroline 2-(3 5-trimethoxybenzyl)-1 2 3 6-tetrahydropyridine N-n-propylmescaline N-cyclopropylmethylmescaline N-allylmescaline |
| Topics | Mescaline |
| Keywords | Stereochemistry Pharmacology |
| Citations | 4 |
| Key finding | The synthesized compounds were evaluated for their ability to antagonize mescaline-induced disruption of swim behavior, and the results are presented. |
Abstract
1-[2-(3,4,5-Trimethoxyphenyl)ethyl]-3-pyrroline, 2-(3,4,5-trimethoxybenzyl)-1,2,3,6-tetrahydropyridine, N-n-propylmescaline, N-cyclopropylmethylmescaline, and N-allylmescaline were synthesized as potential mescaline antagonists. The ability of these compounds to antagonize mescaline-induced disruption of swim behavior is also given.