NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS
R. Shafik, N. Eshba, M. El-Semary, M. Abdel-Kreem
Bulletin of Pharmaceutical Sciences. Assiut University May 26, 2026 DOI: 10.21608/bfsa.1994.69795 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Mescaline |
| Key points | Proposes that novel structural hybrids of mescaline and PCP analogs should be synthesized to investigate potential antagonistic activity at central PCP receptors, but no experimental data are reported. |
Abstract
The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs. The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation. The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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State of the evidence: Mescaline Unclear
Proposes synthesizing structural hybrids of mescaline with PCP analogs to test potential antagonism at central PCP receptors, with no experimental data reported.
Synthesized
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