Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice.
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi, Yasuhiro Fujikawa, Showa Ueki
The Japanese Journal of Pharmacology 1992 DOI: 10.1254/jjp.59.419 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Idebenone Minaprine Nebracetam Tetrahydroaminoacridine NIK-247 Physostigmine |
| Dose | Mescaline 100 mg/kg s.c.; Idebenone 32 and 100 mg/kg i.p.; Minaprine 0.32-10 mg/kg p.o.; Nebracetam 100 mg/kg p.o.; Tetrahydroaminoacridine 1 and 10 mg/kg p.o.; NIK-247 10 and 18 mg/kg p.o.; Physostigmine 0.32 mg/kg i.p. |
| Measures | head-twitch count |
| Topics | Mescaline |
| Keywords | Physostigmine Pharmacology Nootropic Cholinesterase Cholinergic Piracetam Idebenone Acetylcholine |
| Citations | 7 |
| Key points | Idebenone, minaprine, nebracetam, and several cholinesterase inhibitors reduced mescaline-induced head-twitches in mice, suggesting cholinergic activation may be involved. |
Abstract
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |