THE ANTIDOTAL ACTION OF SODIUM SUCCINATE IN THE MESCALINE PSYCHOSIS
Ian Stevenson, Andrew J. Sanchez
American Journal of Psychiatry October 1, 1957 DOI: 10.1176/ajp.114.4.328 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Human subjects experiencing mescaline psychosis |
| Intervention | Sodium succinate |
| Topics | Mescaline |
| Keywords | Psychosis Succinates Sodium Pharmacology |
| Citations | 8 |
| Key findings | Sodium succinate had a definite but transient antidotal effect on mescaline psychosis in all 12 subjects, likely by providing an alternative oxidative substrate in the brain. |
Abstract
1. Sodium succinate was found to have a definite antidotal effect on the mescaline psychosis in each of 12 subjects. 2. The effect varied greatly in different subjects. Moreover, the effect was rather transient and there was little shortening of the total duration of mescaline effect. 3. The most plausible hypothesis of the succinate effect is that succinate provides a substrate for oxidation in the brain tissues when the oxidation of other substrates, e.g., glucose, lactate and pyruvate has been depressed by the mescaline.
Comparable studies
Other observational and cohort studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Long-lasting subjective effects of LSD in normal subjects Healthy participants | 2017 | Observational cohort | n = 16 |
| Psychological and cognitive effects of long-term peyote use among Native Americans. Navajo Native Americans aged 18-45 | 2005 | Observational cohort | n = 176 |
| Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Normal men who were volunteers | 1992 | Observational cohort | n = 12 |
| 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug Normal control volunteers | 1967 | Observational study |