EXPERIMENTALLY PRODUCED PSYCHOSES
American Journal of Psychiatry February 1, 1951 DOI: 10.1176/ajp.107.8.607 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Schizophrenic patients and normal voluntary controls |
| Intervention | Intravenous injection of synthetic mescaline |
| Topics | Mescaline |
| Keywords | Psychosurgery Schizophrenia object-oriented programming Psychosis Lobotomy Psychotherapist Hallucinogen |
| Citations | 41 |
| Key findings | Mescaline can reactivate psychosis in patients who improved after psychosurgery, but the response is quantitatively less conspicuous than before surgery. |
Abstract
Intravenous injection of synthetic mescaline was used in a group of schizophrenic patients and on "normal" voluntary controls. The changes produced by mescaline in "normals" were described. In addition, the observations were made that mescaline is able to underscore in patients suffering from schizophrenia their schizophrenic symptoms or able to precipitate schizophrenic psychoses in persons suffering from latent schizophrenia. Different "therapeutic measures" were discussed as applied to the mescaline-produced abnormal mental states. Mescaline was also given to a number of patients before and after psychosurgery. It was found that with mescaline it was possible to reactivate the psychosis in patients who improved after psychosurgery but that their response to the drug was quantitatively less conspicuous than before.
Comparable studies
Other observational and cohort studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Long-lasting subjective effects of LSD in normal subjects Healthy participants | 2017 | Observational cohort | n = 16 |
| Psychological and cognitive effects of long-term peyote use among Native Americans. Navajo Native Americans aged 18-45 | 2005 | Observational cohort | n = 176 |
| Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Normal men who were volunteers | 1992 | Observational cohort | n = 12 |
| 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug Normal control volunteers | 1967 | Observational study |
Citations in the library
Cited by 12
- Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. Pharmacology & Therapeutics May 1, 2019
- Acute Effects of Drug Abuse in Schizophrenic Patients: Clinical Observations and Patients' Self-reports Schizophrenia Bulletin 1990
- d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology International Journal of Molecular Sciences November 23, 2016
- EFFECT OF DRUGS American Journal of Psychiatry February 1, 1952
- LSD, madness and healing: Mystical experiences as possible link between psychosis model and therapy model. Psychological Medicine March 1, 2023
and 7 more in the library