Stimulation of human prolactin secretion by mescaline
Lothar Demisch, Manfred Neubauer
Psychopharmacology September 1, 1979 DOI: 10.1007/bf00427525 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled study Peer reviewed |
|---|---|
| Population | Humans |
| Interventions | Mescaline 2 3 4-trimethoxy-beta-phenylethylamine |
| Dose | 5 mg/kg |
| Topics | Mescaline |
| Keywords | Stimulation Prolactin Secretion Endocrinology Pharmacology |
| Citations | 8 |
| Key points | Mescaline stimulated prolactin secretion more than four-fold above baseline and triggered growth hormone secretion, while the non-hallucinogenic 2,3,4-TMPEA had no effect. |
Abstract
Prolactin (PRL) and Growth Hormone (GH) secretions were studied in human serum after the oral administration of 5 mg/kg mescaline (3,4,5-trimethoxy-beta-phenylethylamine) or 2,3,4-trimethoxy-beta-phenylethylamine (2,3,4-TMPEA) respectively. Mescaline stimulated the secretion of PRL more than four-fold above base-line levels. Peak concentrations were found 90--120 min after drug intake. Five hours later serum PRL was still markedly increased. Mescaline also triggered GH secretion. There was no alteration of serum PRL and GH concentrations after intake of the non-hallucinogenic 2,3,4-TMPEA.
Citations in the library
Cited by 5
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- Taking birth trauma seriously. Medical Hypotheses 1986
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- Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Archives of General Psychiatry February 1, 1994
- Neuroendocrine and cardiovascular effects of MDE in healthy volunteers. Neuropsychopharmacology May 1993
Cites 5
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Science May 21, 1976
- Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Journal of Pharmacy and Pharmacology September 1, 1978
- Stimulation of rat prolactin secretion by indolealkylamine hallucinogens. Psychopharmacology April 11, 1978
- Effects of LSD-25 on brain serotonin. Journal of Pharmacology and Experimental Therapeutics November 1, 1961