Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes
Biochemical Journal May 1, 1970 DOI: 10.1042/bj1170961 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Goat brain-cortex slices |
| Intervention | Mescaline sulphate |
| Topics | Mescaline |
| Keywords | Ribosome Ribosomal rna Ribonuclease Cortex anatomy Trypsin Biochemistry Enzyme Pharmacology |
| Citations | 12 |
| Key findings | Mescaline sulfate induces ribosomal breakdown and loss of enzyme activity in goat brain-cortex slices without altering ribosomal chemical or nucleotide composition. |
Abstract
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline does not alter the chemical and nucleotide compositions or the u.v.-absorption characteristics of ribosomal particles, however.