Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
Abhishek K. Sen, J. Andrew Jones
Trends in biochemical sciences March 1, 2024 DOI: 10.1016/j.tibs.2023.12.009 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT DMT |
| Keywords | N-methylation Psychedelic indolethylamine Serotonin receptor binding Psychedelic-Compounds DMT Neuroscience serotonin Neurot Biochemistry |
| Citations | 2 |
| Key findings | RmNMT from the cane toad is a highly active and promiscuous tryptamine N-methyltransferase that produces DMT derivatives evaluated as potential treatments for mental health disorders. |
Abstract
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.