Mystical and Ego-Dissolution Experiences in Ayahuasca and Jurema Holistic Rituals: An Exploratory Study
Robson Savoldi, Antônio Roazzi, Rita Clara de Oliveira Sales
International Journal for the Psychology of Religion April 13, 2023 DOI: 10.1080/10508619.2023.2185369 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 26 |
| Population | Participants in ayahuasca and jurema rituals in a natural environment |
| Interventions | Ayahuasca Jurema |
| Topics | Ayahuasca Mysticism Ego dissolution Mystical experience |
| Keywords | Subjectivity Psychic |
| Citations | 6 |
| Key findings | Ayahuasca sessions produced significantly higher scores for temporal quality, ineffability, and religious quality than jurema sessions, with setting playing a key role in the differences. |
Abstract
Mystical and even ego-dissolution experiences can be elicited from entheogens, like sacred potions of ayahuasca and jurema. Although composed of dimethyltryptamine (DMT) and having met at a historical moment, ayahuasca and jurema have different rituals, symbolic references, and origins. This article aims to describe ayahuasca and jurema rituals, in psychometric measures of mysticism and ego-dissolution experience and set/settings. Observational data were collected through the Hood Mysticism Scale and Ego Dissolution Inventory in a sample of 26 participants, and semi-structured interviews (n = 7), in a natural environment. Results showed that in the ayahuasca session, means for temporal quality, ineffability, and religious quality were significantly higher than in the jurema session, but no significant differences were found in the other facets of the ego-dissolution. In the ayahuasca session, EDI was positively significantly correlated with temporal and unifying quality, whereas in the jurema session, EDI was positively significantly correlated with religious, unifying, and inner subjectivity qualities. Ethnographic observations and interviews reveal that the setting plays a key role in those differences and the meaning of the experience. More studies are needed to improve our understanding of how the set/setting interacts in mystical experiences.
Comparable studies
Other observational and cohort studies on ego dissolution, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution Non-pathological ayahuasca ceremony attendees in the Netherlands and Colombia | 2018 | Observational cohort | n = 57 |
| From Egoism to Ecoism: Psychedelics Increase Nature Relatedness in a State-Mediated and Context-Dependent Manner. Individuals planning to use a psychedelic | 2019 | Prospective online study | n = 654 |
| Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings. Healthy and experienced participants | 2021 | Observational field study | n = 35 |
| Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self Healthy volunteers | 2025 | Observational cohort | n = 14 |
Citations in the library
Cited by 7
- Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors. Cellular and Molecular Life Sciences September 10, 2024
- Cross-validation of the ego dissolution scale: implications for studying psychedelics. Frontiers in Neuroscience December 5, 2023
- A Scoping Review of Research in Naturalistic Studies with Psychedelics. Journal of Psychoactive Drugs June 28, 2025
- The Effects of Ayahuasca on Psychological Disorders: A Systematic Literature Review. Cureus March 1, 2024
- Seasonal Effect on the Chemical Composition of Mimosa tenuiflora (Willd.) Poir Stem Bark from the Semi‐Arid Region of Pernambuco, Brazil Chemistry & Biodiversity September 23, 2025
and 2 more in the library
Cites 67
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology December 1, 2011
- Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later Journal of Psychopharmacology May 30, 2008
- Psychedelics and the essential importance of context. Journal of Psychopharmacology February 15, 2018
and 62 more in the library