The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity
Harold A. Abramson, H. H. Gettner, P. A. Carone, Anabela P. Rolo, Leonard W. Krinsky
Journal of Asthma Research 1979 DOI: 10.3109/02770907909106614 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Goldfish weighing up to three grams |
| Interventions | d-2-acetyl lysergic acid diethylamide (ALD-52) 1-methyl d-lysergic acid butano-lamide (UML-491) and 5-methoxy dimethyl tryptamine (5-MEO-DMT) |
| Topics | LSD Serotonin |
| Keywords | Tryptamine Hallucinogen Pharmacology Fish <actinopterygii> Stereochemistry |
| Citations | 4 |
| Key findings | D-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active in goldfish as previously noted in fish and in humans. |
Abstract
A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected intracranially. Employing this method, d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butano-lamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were found to be as pharmacologically active as previously noted in fish and in man. The relationship of these drugs to their anti-serotonin activity is of particular interest to the allergist because of the way in which the congeners and derivatives of LSD block the action of serotonin on smooth muscle.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 3
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research June 1, 2010