INHIBITION OF THE SECRETION OF INTERMEDINE BY D-LYSERGIC ACID DIETHYLAMIDE (LSD 25) IN THE TOAD, XENOPUS LAEVIS
A. C. J. Burgers, W. Leemreis, Tadeusz Dominiczak, G. J. van Oordt
European Journal of Endocrinology October 1, 1958 DOI: 10.1530/acta.0.0290191 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | D-lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Chromatophore Toad Melanophore Xenopus Poecilia Fish <actinopterygii> Endocrinology Zoology Pharmacology |
| Citations | 18 |
| Key findings | LSD causes pigment dispersion in the melanophores of female guppies in vivo and in vitro, indicating a direct effect on dermal melanophores. |
Abstract
In the last ten years the psychic actions of the drug D-lysergic acid diethylamide LSD-251, delysid (Sandoz Ltd, Basle)] have been extensively studied in man and other mammals. Little work, however, has been done on its action in lower Vertebrates. It was found that in fishes and amphibians the influence of LSD manifests itself in both behaviour- and colour-changes. Besides characteristic changes in behaviour a distinct darkening of the teleost fish Betta splendens was obtained with LSD by Abramson & Evans (1954) and Evans et al. (1956). Moreover, Cerletti & Berde (1955), and Berde & Cerletti (1956, 1957) demonstrated that LSD causes a marked pigment dispersion in the melanophores of the female guppy, Lebistes (= Poecilia) reticulatus, in vivo as well as in vitro. Hence, the last mentioned authors assumed that LSD acts directly on the dermal melanophores of this fish. Kahr & Fischer (1957) injected LSD into normal and