The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity
Harold A. Abramson, H. H. Gettner, P. A. Carone, Anabela P. Rolo, Leonard W. Krinsky
Journal of Asthma Research 1979 DOI: 10.3109/02770907909106614 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Goldfish weighing up to three grams |
| Interventions | d-2-acetyl lysergic acid diethylamide (ALD-52) 1-methyl d-lysergic acid butano-lamide (UML-491) and 5-methoxy dimethyl tryptamine (5-MEO-DMT) |
| Topics | LSD Serotonin |
| Keywords | Tryptamine Hallucinogen Pharmacology Fish <actinopterygii> Stereochemistry |
| Citations | 4 |
| Key findings | D-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active in goldfish as previously noted in fish and in humans. |
Abstract
A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected intracranially. Employing this method, d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butano-lamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were found to be as pharmacologically active as previously noted in fish and in man. The relationship of these drugs to their anti-serotonin activity is of particular interest to the allergist because of the way in which the congeners and derivatives of LSD block the action of serotonin on smooth muscle.