LSD-Induced Decrease in Serum Prolactin in Rats
S. K. Quadri, J. Meites
Experimental Biology and Medicine September 1, 1971 DOI: 10.3181/00379727-137-35764 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Female rats on the morning of proestrus |
| Intervention | LSD |
| Dose | 25, 50, or 100 μg per 100 g of body weight |
| Topics | LSD |
| Keywords | Prolactin Endocrinology Morning Pharmacology |
| Citations | 7 |
| Key findings | LSD injection on the morning of proestrus significantly decreased serum prolactin levels and prevented the normal afternoon rise in female rats. |
Abstract
SummaryA single ip injection of 25, 50, or 100 μg of LSD (lysergic acid diethylamide)/100 g of body weight into female rats on the morning of proestrus significantly decreased serum prolactin levels, and prevented the normal rise observed in control rats on the afternoon of proestrus. The 100-μg dose of LSD produced a significantly greater decrease in serum prolactin than the 25-μg dose. This action of LSD is shared by other ergot drugs.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 3
- Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro Life Sciences June 1, 1998
- Menstrual Changes and Reversal of Amenorrhea Induced by Classic Psychedelics: A Case Series Journal of Psychoactive Drugs January 22, 2023
- Lysergic acid diethylamide: Evidence for stimulation of pituitary dopamine receptors Psychopharmacology 1977