Severe Neurological Sequelae after a Recreational Dose of LSD
Rachel Aakerøy, Wenche Rødseth Brede, Stian Bergseng Stølen, Hege‐merete Krabseth, Lisbeth Solem Michelsen, Trine Naalsund Andreassen, Tiina Ader, Joachim Frost, Grete Slettom, Ole Martin Steihaug, Lars Slørdal
Journal of Analytical Toxicology October 2, 2020 DOI: 10.1093/jat/bkaa145 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A young man with unremarkable medical history |
| Topics | LSD |
| Keywords | Cardiorespiratory fitness Adverse effect Recreational use Serum concentration Cardiorespiratory arrest Physiology Pharmacology Anesthesia |
| Citations | 9 |
| Key findings | LSD may cause seizure, cardiorespiratory arrest, and severe neurological sequelae in previously healthy individuals. |
Abstract
Abstract A young man with an unremarkable medical history suffered a seizure with subsequent cardiorespiratory arrest and severe neurological sequelae after ingesting a blotter. Analysis of a similar blotter and a serum sample obtained 3 h after the event detected lysergic acid diethylamide (LSD) at an amount of 300 µg in the blotter and at a concentration of 4.0 ng/mL (12.4 nmol/L) in the serum. No other drugs were present in concentrations which may confer significant effects. In addition, no individual traits which would make the patient particularly susceptible to adverse LSD effects have subsequently been identified. This suggests that LSD may confer toxic effects in previously healthy individuals.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cited by 8
- Assessing the risk–benefit profile of classical psychedelics: a clinical review of second-wave psychedelic research Psychopharmacology January 13, 2022
- Molecular and clinical aspects of potential neurotoxicity induced by new psychoactive stimulants and psychedelics Experimental Neurology June 4, 2021
- Psychedelic Psychiatry and the Consult-Liaison Psychiatrist: A Primer Journal of the Academy of Consultation-Liaison Psychiatry January 21, 2021
- Psychedelics, epilepsy, and seizures: a review Frontiers in Pharmacology January 12, 2024
- Case report: Psychedelic-induced seizures captured by intracranial electrocorticography Frontiers in Neurology June 29, 2023
and 3 more in the library
Cites 6
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects Clinical Pharmacokinetics February 14, 2017
- Is LSD toxic? Forensic Science International March 1, 2018
- Does getting high hurt? Characterization of cases of LSD and psilocybin-containing mushroom exposures to national poison centers between 2000 and 2016 Journal of Psychopharmacology September 5, 2018
- The dark side of ecstasy: neuropsychiatric symptoms after exposure to 3,4-methylenedioxymethamphetamine. Basic & Clinical Pharmacology & Toxicology January 2008
and 1 more in the library