Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Allen P. Fertziger, Roland Fischer
Psychopharmacology 1977 DOI: 10.1007/bf00426582 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD naloxone |
| Topics | LSD Serotonin |
| Keywords | Catalepsy +-naloxone Pharmacology Endorphins Narcotic antagonists Anesthesia Endocrinology Haloperidol Receptor Dopamine |
| Citations | 12 |
| Key findings | LSD produces a diphasic reaction in rats—brief excitement followed by prolonged catalepsy—and naloxone has opposite effects depending on whether it is given before or after LSD. |
Abstract
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 5
- Naloxone potentiates the disruptive effects of mescaline on operant responding in the rat Pharmacology, Biochemistry, and Behavior October 1, 1980
- Effects of Psychedelics Lysergic Acid Diethylamide and R (–)-2,5-Dimethoxy-4-Iodoamphetamine on Oral Opioid Consumption and Naloxone-Precipitated Withdrawal in Male C57Bl/6J Mice Psychedelic Medicine March 28, 2026
- Naloxone alters the effects of LSD, DOM and quipazine on operant behavior of rats. Pharmacology, Biochemistry, and Behavior September 1984
- Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat. Psychopharmacology 1981
- Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat. Psychopharmacology April 25, 1979