Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Psychopharmacology 1977 Allen P. Fertziger, Roland Fischer 12 citations
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
DOI: 10.1007/bf00426582 (opens in new tab)
Lysergic acid diethylamide
Serotonin
Catalepsy
+-naloxone
+8