Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Allen P. Fertziger, Roland Fischer
Psychopharmacology 1977 DOI: 10.1007/bf00426582 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD naloxone |
| Topics | LSD Serotonin |
| Keywords | Catalepsy +-naloxone Pharmacology Endorphins Narcotic antagonists Anesthesia Endocrinology Haloperidol Receptor Dopamine |
| Citations | 12 |
| Key findings | LSD produces a diphasic reaction in rats—brief excitement followed by prolonged catalepsy—and naloxone has opposite effects depending on whether it is given before or after LSD. |
Abstract
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.