Effects of diazepam and of serotonin agonists on hyponeophagia in rats.
Neuropharmacology April 1, 1982 DOI: 10.1016/0028-3908(82)90097-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male and female rats |
| Interventions | Fenfluramine 5-MeODMT Diazepam |
| Dose | 2 mg/kg fenfluramine, 2.5 mg/kg 5-MeODMT, 1 mg/kg diazepam |
| Topics | Serotonin |
| Citations | 53 |
| Key findings | Diazepam antagonized the hyponeophagia-enhancing effects of serotonin agonists fenfluramine and 5-MeODMT, suggesting it acts distally to serotonergic drugs. |
Abstract
The effects of serotonin agonists, fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (5-MeODMT, 2.5 mg/kg) on hyponeophagia were studied both alone and in combination with diazepam (1 mg/kg). Male and female rats were used but sex differences were not found. The serotonin agonists enhanced hyponeophagia while diazepam attenuated it and antagonised the actions of both serotonin agonists. These findings are discussed in connection with the serotonin hypothesis of benzodiazepine action with the conclusion that diazepam acts distally to serotonergic drugs on hyponeophagia.
Comparable studies
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| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
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| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 4
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- Hyponeophagia and arousal in rats: effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation. Psychopharmacology 1982
- Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines. Neuropharmacology October 1, 1982
- Hyponeophagia in the Roman rat strains: effects of 5-methoxy-N,N-dimethyltryptamine, diazepam, methysergide and the stereoisomers of propranolol. European Journal of Pharmacology November 25, 1983
Cites 2
- Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Science May 21, 1976
- FURTHER STUDIES ON THE MODE OF ACTION OF PSYCHOTOMIMETIC DRUGS: ANTAGONISM OF THE EXCITATORY ACTIONS OF 5‐HYDROXYTRYPTAMINE BY METHYLATED DERIVATIVES OF TRYPTAMINE British Journal of Pharmacology March 1, 1974