Responses of serotonergic and non-serotonergic neurons in the rat nucleus raphe magnus to systemic lysergic acid diethylamide.
J B Wei, C Y Chiang
Neuroscience Research February 1986 DOI: 10.1016/0168-0102(86)90010-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal electrophysiology study Peer reviewed |
|---|---|
| Population | Neurons of the nucleus raphe magnus (13 serotonergic and 38 non-serotonergic cells) |
| Intervention | LSD |
| Dose | 40-50 micrograms/kg, i.p. or i.v. |
| Topics | LSD Serotonin |
| Key findings | LSD (40-50 micrograms/kg) depressed 8 of 13 serotonergic neurons in the nucleus raphe magnus, with the rest unresponsive. Of 38 non-serotonergic neurons, 5 were depressed, 4 excited, and 29 unaffected. The authors conclude that LSD can act differently on serotonergic and non-serotonergic neurons in this region. |
Abstract
Serotonergic and non-serotonergic neurons in the nucleus raphe magnus were identified by conduction velocities and spontaneous discharge rates. Eight of 13 serotonergic neurons were depressed by lysergic acid diethylamide (LSD) administration (40-50 micrograms/kg, i.p. or i.v.), while the others were non-responsive. Among 38 non-serotonergic neurons, 5 were depressed, 4 were excited and 29 were unaffected by systemic LSD at the same doses. It is thus concluded that LSD could act differently on serotonergic and non-serotonergic neurons in nucleus raphe magnus.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cites 3
- Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science August 16, 1968
- Dissociations Between the Effects of LSD on Behavior and Raphe Unit Activity in Freely Moving Cats Science August 3, 1979
- Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats. Journal of Pharmacology and Experimental Therapeutics 1984