Suppression of LSD-25 Effects in Rats by Steroids.
John R. Bergen, Donald M. Krus, Gregory Pincus
Experimental Biology and Medicine November 1, 1960 DOI: 10.3181/00379727-105-26073 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | steroid hormones and metabolites |
| Topics | LSD |
| Keywords | Potency Hormone Steroid Pharmacology Endocrinology |
| Citations | 13 |
| Key findings | All tested steroid hormones and metabolites except estradiol significantly suppressed LSD-25 induced behavior changes in rats, and this effect was not related to specific molecular groups or hormonal potency. |
Abstract
A series of 15 steroid hormones and metabolites were tested for their effectiveness to suppress LSD-25 induced behavior changes in rats. All produced significant suppression (p<0.05) except estradiol. Ability to suppress LSD-25 action does not appear to be related to specific molecular groups or to hormonal potency.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.