Effects of LSD-25 and Amphetamine on a Running Response in the Rat
Archives of General Psychiatry 1960 DOI: 10.1001/archpsyc.1960.03590070106013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | d-lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Amphetamine Urination Defecation Climbing Anesthesia Physiology |
| Citations | 31 |
| Key findings | LSD-25 injection in rats causes autonomic symptoms and dose-dependent increases in rope-climbing times, with some rats ceasing to climb at the peak drug effect. |
Abstract
After injection ofd-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, urination, and defecation. There is some indication that the somatic nervous system is also involved, since the animal exhibits hyperactivity in the first few minutes after injection, while after three to five minutes there is a tendency for all four legs to flex and the abdomen touches the floor. At this point the animal may remain motionless for long periods if permitted to stay in its living cage undisturbed. These symptoms have been observed by Winter and Flataker1and also by me. Winter and Flataker, in the same study, also observed that for rats trained to climb a rope for food reinforcement, climbing times were increased as a function of dosage levels. At the height of the drug effect some of the rats did not
Comparable studies
Other preclinical and animal studies on LSD, most cited first.