Phantom Limb Pain: Sub‐Hallucinogenic Treatment With Lysergic Acid Diethylamide (LSD‐25)
M Fanciullacci, E. Del Bene, G Franchi, F Sicuteri
Headache: The Journal of Head and Face Pain July 1, 1977 DOI: 10.1111/j.1526-4610.1977.hed1703118.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case series Case report Peer reviewed |
|---|---|
| Sample size | 7 |
| Population | Five males and two females aged 25 to 78 with phantom limb pain |
| Dose | sub-hallucinogenic doses (oral); intravenous infusion or bolus injection of 10 ng/ml at 0.5 ml/min |
| Topics | LSD |
| Keywords | Hallucinogen Analgesic Phantom pain Phantom limb pain Nociception Anesthesia Facilitation |
| Citations | 30 |
| Key findings | Sub-hallucinogenic doses of LSD-25 improved phantom limb pain in five of seven patients and reduced analgesic use. |
Abstract
SYNOPSIS Oral treatment of phantom limb pain in five males and two females ranging in age from 25 to 78 years with sub‐hallucinogenic doses of Iysergic acid diethyImaide (LSD‐25) resulted in improvement in pain in five patients and reduction in use of analgesics. In two of the five patients improvement was striking and in the other three, pain and analgesic use were reduced moderately. LSD treatment was ineffective in two patients. Intravenous infusion or bolus injection of LSD‐25, 10ngml at 0.5 mlmin. resulted in facilitation of 5‐HT venospasm. The findings suggest that LSD‐25 facilitation of 5‐HT activity occurs centrally consistent with the hypothesis of the central nature of phantom limb pain.
Comparable studies
Other case reports and case series on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Further Studies in the Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Patients with mental illness | 1957 | Case series | |
| Coma, Hyperthermia, and Bleeding Associated with Massive LSD Overdose a Report of Eight Cases People who self-administered large amounts of pure LSD powder intranasally | 1975 | Case series | n = 8 |
| Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders Patients with chronic complex post-traumatic stress disorder (c-PTSD), dissociative,... | 2022 | Case series | |
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
Citations in the library
Cited by 26
- Psychedelic-Assisted Psychotherapy—A Systematic Review of Associated Psychological Interventions Frontiers in Psychology June 10, 2022
- Chronic pain and psychedelics: a review and proposed mechanism of action Regional Anesthesia & Pain Medicine May 4, 2020
- A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers Journal of Psychopharmacology August 25, 2020
- Microdosing psilocybin for chronic pain: a case series Pain September 5, 2022
- Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders Molecules April 13, 2022
and 21 more in the library