Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD
Peter K. Gessner, Irvine H. Page
American Journal of Physiology-Legacy Content July 1, 1962 DOI: 10.1152/ajplegacy.1962.203.1.167 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Trained rats |
| Interventions | 5-Methoxy-N:N-dimethyltryptamine N:N-dimethyltryptamine N:N-diethyltryptamine 5-hydroxy-N:N-dimethyltryptamine (bufotenine) LSD-25 |
| Dose | 19 µm/kg for 5-MeO-DMT; 25 µm/kg for DMT, DET, bufotenine; 6 µm/kg for LSD-25 |
| Topics | Psilocybin Serotonin 5-MeO-DMT DMT LSD |
| Keywords | Tryptamines Hallucinogen Psychotomimetic Pharmacology |
| Citations | 64 |
| Key findings | 5-Methoxy-N:N-dimethyltryptamine had a more pronounced effect on the conditioned avoidance response in rats than other substituted tryptamines, comparable to LSD-25, suggesting a potential link between abnormal tryptophan metabolism and mental disturbance. |
Abstract
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic substituted tryptamines: N:N-dimethyltryptamine, N:N-diethyltryptamine, and 5-hydroxy-N:N-dimethyltryptamine (bufotenine) at the higher dose level of 25 µm/kg. A similar response was elicited by LSD-25 at a dose level of 6 µm/kg. Both hydroxyindole-O-methylase and an enzyme capable of N-methylating indoleethylamines occur in mammals. This circumstance makes it possible to form 5-methoxy-N:N-dimethyltryptamine from such substrates as serotonin. The pronounced behavioral effect of this and similar methoxyindolealkylamine suggests that abnormal tryptophan metabolism could result in mental disturbance.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cited by 12
- Bufo alvarius: a potent hallucinogen of animal origin. Journal of Ethnopharmacology 1994
- Bufo toads and bufotenine: fact and fiction surrounding an alleged psychedelic. Journal of Psychoactive Drugs 1996
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- Local cerebral glucose utilisation following indoleamine- and piperazine-containing 5-hydroxytryptamine agonists. Journal of Neurochemistry 1986
- Identity of a New World Psychoactive Toad Ancient Mesoamerica 1992
and 7 more in the library