LSD-Like Panic From Risperidone in Post-LSD Visual Disorder
Henry David Abraham, Anitra Mamen
Journal of Clinical Psychopharmacology June 1, 1996 DOI: 10.1097/00004714-199606000-00008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Patients with hallucinogen-persisting perception disorder (HPPD) |
| Intervention | Risperidone |
| Topics | Anxiety LSD |
| Keywords | Risperidone |
| Citations | 50 |
| Key findings | Three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. |
Abstract
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.
Comparable studies
Other case reports and case series on LSD for anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Persistent Palinopsia Following Ingestion of Lysergic Acid Diethylamide (LSD) Patients who developed persistent palinopsia after LSD ingestion | 1996 | Case series | n = 3 |
| Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects A 39-year-old female patient with severe, treatment-resistant depression and complex... | 2020 | Case study | n = 1 |
| LSD Overdoses: Three Case Reports Three individuals who experienced accidental LSD overdose | 2020 | Case series | n = 3 |
| BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS A client experiencing spontaneous recurrences of LSD effects | 1973 | Case study | n = 1 |
| Single-dose 1cp-LSD administration for canine anxiety: a pilot study. A 13-year-old female mixed-breed dog with separation anxiety | 2024 | Case study | n = 1 |
Citations in the library
Cited by 20
- Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives Brain Sciences March 16, 2018
- The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Frontiers in Psychiatry November 20, 2017
- Hallucinogen persisting perception disorder after psilocybin consumption: a case study European Psychiatry June 18, 2005
- Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention, and treatment Expert Opinion on Drug Safety April 15, 2022
- Adverse psychiatric effects of psychedelic drugs: a systematic review of case reports. Psychological Medicine November 20, 2024
and 15 more in the library
Cites 9
- Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences December 17, 1984
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- Visual Phenomenology of the LSD Flashback Archives of General Psychiatry August 1, 1983
- Adverse consequences of lysergic acid diethylamide Addiction October 1, 1993
- Flashbacks: Recurrent Intrusive Images After the Use of LSD American Journal of Psychiatry October 1, 1969
and 4 more in the library