Are Auditory Hallucinations Related to the Brain's Resting State Activity? A 'Neurophenomenal Resting State Hypothesis'
Clinical Psychopharmacology and Neuroscience December 26, 2014 DOI: 10.9758/cpn.2014.12.3.189 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Resting State FMRI Auditory cortex Stimulus psychology Confusion Auditory imagery Audiology Cognitive psychology Cognition |
| Citations | 65 |
| Key points | Proposes that auditory verbal hallucinations in schizophrenia may be traced back to abnormally elevated resting state activity in the auditory cortex, abnormal modulation by the default-mode network, and neural confusion between resting state changes and stimulus-induced activity. |
Abstract
While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally elevated resting state activity in auditory cortex itself, abnormal modulation of the auditory cortex by anterior cortical midline regions as part of the default-mode network, and neural confusion between auditory cortical resting state changes and stimulus-induced activity. We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenal, i.e., subjective-experiential features as explored in phenomenological accounts. Therefore I speak of a 'neurophenomenal resting state hypothesis' of auditory hallucinations in schizophrenia.
Comparable studies
Other theoretical and historical papers on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs | 2014 | Theoretical or philosophical paper | |
| The default mode network in cognition: a topographical perspective | 2021 | Theoretical or philosophical paper | |
| The default mode network: where the idiosyncratic self meets the shared social world | 2021 | Theoretical or philosophical paper | |
| The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas | 2010 | Theoretical or philosophical paper | |
| Cooperation between the default mode network and the frontal–parietal network in the production of an internal train of thought | 2011 | Theoretical or philosophical paper |
Citations in the library
Cited by 7
- Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence Psychiatry Research January 14, 2020
- Is the Sense of Agency in Schizophrenia Influenced by Resting-State Variation in Self-Referential Regions of the Brain? Schizophrenia Bulletin July 28, 2015
- Topographic-dynamic reorganisation model of dreams (TRoD) - A spatiotemporal approach. Neuroscience & Biobehavioral Reviews May 1, 2023
- From neuronal to mental topography - Neurophenomenology of auditory hallucinations. Translational Psychiatry November 21, 2025
- What physics offers for artificial intelligence? Lessons from the brain's inner time and its dynamics. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences May 14, 2026
and 2 more in the library
Cites 5
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis Schizophrenia Bulletin October 6, 2012
- Self‐experience in the early phases of schizophrenia: 5‐year follow‐up of the Copenhagen Prodromal Study World Psychiatry October 1, 2011
- Neuroimaging of voice hearing in non-psychotic individuals: a mini review. Frontiers in Human Neuroscience May 9, 2012
- Do we need multiple models of auditory verbal hallucinations? Examining the phenomenological fit of cognitive and neurological models. Schizophrenia Bulletin September 26, 2008