LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids.
Marcelo N. Costa, Livia Goto-Silva, Juliana Nascimento, Ivan Domith, Karina Karmirian, Amanda Feilding, Pablo Trindade, Daniel Martins-de-Souza, Stevens K. Rehen
ACS Omega August 27, 2024 DOI: 10.1021/acsomega.4c04712 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Human cerebral organoids |
| Intervention | LSD |
| Topics | LSD Neuroplasticity |
| Keywords | Mental health Drug effects Psychedelics Brain research |
| Citations | 3 |
| Key findings | LSD exposure alters proteins involved in proteostasis, energy metabolism, and neuroplasticity-related pathways in human cerebral organoids. |
Abstract
Proteomic analysis of human cerebral organoids may reveal how psychedelics regulate biological processes, shedding light on drug-induced changes in the brain. This study elucidates the proteomic alterations induced by lysergic acid diethylamide (LSD) in human cerebral organoids. By employing high-resolution mass spectrometry-based proteomics, we quantitatively analyzed the differential abundance of proteins in cerebral organoids exposed to LSD. Our findings indicate changes in proteostasis, energy metabolism, and neuroplasticity-related pathways. Specifically, LSD exposure led to alterations in protein synthesis, folding, autophagy, and proteasomal degradation, suggesting a complex interplay in the regulation of neural cell function. Additionally, we observed modulation in glycolysis and oxidative phosphorylation, crucial for cellular energy management and synaptic function. In support of the proteomic data, complementary experiments demonstrated LSD's potential to enhance neurite outgrowth in vitro, confirming its impact on neuroplasticity. Collectively, our results provide a comprehensive insight into the molecular mechanisms through which LSD may affect neuroplasticity and potentially contribute to therapeutic effects for neuropsychiatric disorders.
Comparable studies
Other observational and cohort studies on neuroplasticity, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Neural correlates of attentional expertise in long-term meditation practitioners Age-matched participants including expert meditators and novices | 2007 | Observational cohort | |
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Functional Reorganization of the Default Mode Network across Chronic Pain Conditions Patients with chronic back pain, complex regional pain syndrome, and knee osteoarthritis | 2014 | Observational cohort | |
| State and Training Effects of Mindfulness Meditation on Brain Networks Reflect Neuronal Mechanisms of Its Antidepressant Effect Novice meditators | 2016 | Longitudinal study | n = 13 |
Citations in the library
Cited by 2
Cites 19
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Science February 16, 2023
- Psychedelics promote plasticity by directly binding to BDNF receptor TrkB Nature Neuroscience June 1, 2023
- Psychedelics reopen the social reward learning critical period Nature June 14, 2023
- Towards an understanding of psychedelic-induced neuroplasticity. Neuropsychopharmacology 2023
and 14 more in the library