Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines.
R A Shephard, D A Buxton, P L Broadhurst
Neuropharmacology October 1, 1982 DOI: 10.1016/0028-3908(82)90117-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-MeODMT chlordiazepoxide pCPA |
| Dose | 1.0 and 3.0 mg/kg 5-MeODMT, 5 or 10 mg/kg chlordiazepoxide, 100 mg/kg pCPA |
| Topics | Serotonin |
| Citations | 59 |
| Key findings | 5-MeODMT reversed the anti-conflict effects of chronic pCPA but did not affect punished behavior alone or with chlordiazepoxide, and chronic pCPA did not prevent chlordiazepoxide's effects. |
Abstract
Interactions between 5-methoxy, N,N-dimethyltryptamine (5-MeODMT), chlordiazepoxide and para-chlorophenylalanine (pCPA) on conflict behaviour were studied. 5-Methoxy, N,N-dimethyltryptamine (1.0 and 3.0 mg/kg), induced observable effects and reduced unpunished response rates but did not affect punished behaviour either alone, on in the presence of 5 or 10 mg/kg chlordiazepoxide. However, 5-MeODMT (1 mg/kg) reversed the anti-conflict effects of chronic administration of pCPA (100 mg/kg). Chronic administration of pCPA did not prevent the increase in punished response rates induced by chlordiazepoxide (5 mg/kg). These findings are discussed in the context of the serotonin hypothesis of benzodiazepine action, with the conclusion that benzodiazepines act at a site distal to that of serotonergic drugs on conflict behaviour.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 3
- Anti-aversive role of serotonin in the dorsal periaqueductal grey matter. Psychopharmacology 1985
- Hyponeophagia and arousal in rats: effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation. Psychopharmacology 1982
- Hyponeophagia in the Roman rat strains: effects of 5-methoxy-N,N-dimethyltryptamine, diazepam, methysergide and the stereoisomers of propranolol. European Journal of Pharmacology November 25, 1983
Cites 4
- Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor British Journal of Pharmacology December 1, 1971
- Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Science May 21, 1976
- FURTHER STUDIES ON THE MODE OF ACTION OF PSYCHOTOMIMETIC DRUGS: ANTAGONISM OF THE EXCITATORY ACTIONS OF 5‐HYDROXYTRYPTAMINE BY METHYLATED DERIVATIVES OF TRYPTAMINE British Journal of Pharmacology March 1, 1974
- Effects of diazepam and of serotonin agonists on hyponeophagia in rats. Neuropharmacology April 1, 1982