Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain.
Neuroscience Letters April 1, 1993 DOI: 10.1016/0304-3940(93)90472-w (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal pharmacology experiment Peer reviewed |
|---|---|
| Population | Rat brain tissue (synaptosomes) and rats |
| Interventions | 3 4-methylenedioxymethamphetamine (MDMA) p-nitrobenzylpiperazine p-chlorobenzylpiperazine 1-piperonylpiperazine desipramine imipramine |
| Duration | 3 hours after MDMA administration |
| Topics | Serotonin MDMA |
| Keywords | Synaptosomes Animals Rats, wistar N-methyl-3,4-methylenedioxyamphetamine Hydroxyindoleacetic acid Piperazines Desipramine Imipramine Brain chemistry Male |
| Key findings | Coadministering benzylpiperazine derivatives significantly attenuated MDMA-induced serotonin reduction in rat brain, while the stronger serotonin uptake inhibitors desipramine and imipramine did not. The authors suggest these benzylpiperazines may inhibit MDMA's acute effects via a mechanism other than serotonin uptake inhibition. |
Abstract
The reduction of 5-hydroxytryptamine (5-HT) in rat brain 3 h after administration of 3,4-methylenedioxymethamphetamine (MDMA) was attenuated significantly by coadministration of benzylpiperazine derivatives (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors of [3H]5-HT uptake into rat brain synaptosomes. However, the coadministration of desipramine and imipramine which were more potent 5-HT uptake inhibitors than these benzylpiperazines, did not attenuate the reduction of 5-HT by MDMA. These results suggest that these benzylpiperazines might inhibit the acute effects of MDMA by a novel neuropharmacological effect other than 5-HT uptake inhibition.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 2
- Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug–drug interactions Critical Reviews in Toxicology October 3, 2012
- Qualitative Research of Online Drug Misuse Communities with Reference to the Novel Psychoactive Substances University of Hertfordshire Research Archive May 29, 2013
Cites 6
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- Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine. European Journal of Pharmacology September 1, 1992
- 5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. European Journal of Pharmacology February 20, 1990
- Reduction of [3H]6-nitroquipazine-labelled 5-hydroxytryptamine uptake sites in rat brain by 3,4-methylenedioxymethamphetamine. Fundamental and Clinical Pharmacology 1990
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