Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography.
B R Sitaram, R Talomsin, G L Blackman, W R Mcleod
Biochemical Pharmacology May 1, 1987 DOI: 10.1016/0006-2952(87)90117-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Rat tissue extracts |
| Interventions | N N-dimethyltryptamine 5-methoxy-N |
| Citations | 23 |
| Key points | Metabolites of N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine were separated and characterized, and metabolic routes in rat liver, kidney, and brain extracts included oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. |
Abstract
The use of a series of liquid chromatographic techniques involving cation-exchange, reverse-phase and normal-phase chromatography has permitted the separation and characterisation of a number of metabolites of the psychotomimetic indolealkylamines N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine which were isolated following incubation of these compounds with rat tissue extracts. In liver, kidney and brain tissue extracts the routes of metabolism identified included oxidative deamination, N-demethylation, O-demethylation and N-oxidation. The quantitative significance of individual routes of metabolism in these tissues was assessed using N,N-dimethyltryptamine as a substrate.
Citations in the library
Cited by 12
- Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Current Drug Metabolism October 1, 2010
- Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study Drug Testing and Analysis July 28, 2014
- Metabolism and disposition of N,N‐dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca Drug Testing and Analysis April 19, 2012
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat. Biochemical Pharmacology May 1, 1987
and 7 more in the library