R Talomsin

2 papers in the library · 98 citations · publishing 1987

Papers

In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat.

Biochemical Pharmacology May 1, 1987 B R Sitaram, L Lockett, R Talomsin et al. 75 citations

After injection into the abdominal cavity, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are rapidly taken up by and cleared from all tissues examined. Live-animal experiments confirm earlier lab findings that these compounds are metabolized through oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. Analysis of metabolic profiles across tissues identified N-oxides as major metabolites. Pretreating animals with iproniazid successfully inhibited and redirected metabolism away from indole acids toward the parent compounds and their structurally unique metabolites.

DOI: 10.1016/0006-2952(87)90118-3 Full text

Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography.

Biochemical Pharmacology May 1, 1987 B R Sitaram, R Talomsin, G L Blackman et al. 23 citations

Using liquid chromatography techniques, metabolites of the psychotomimetic compounds N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine were separated and characterized after incubation with rat tissue extracts. In liver, kidney, and brain extracts, metabolic routes included oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The quantitative importance of each route was assessed using N,N-dimethyltryptamine as a substrate.

DOI: 10.1016/0006-2952(87)90117-1 Full text