In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat.
B R Sitaram, L Lockett, R Talomsin, G L Blackman, W R Mcleod
Biochemical Pharmacology May 1, 1987 DOI: 10.1016/0006-2952(87)90118-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vivo study Peer reviewed |
|---|---|
| Population | Animals |
| Intervention | iproniazid |
| Topics | 5-MeO-DMT DMT |
| Citations | 75 |
| Key points | N-oxides are major metabolites of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine, and iproniazid pretreatment redirects metabolism away from indole acids toward parent compounds and unique metabolites. |
Abstract
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The analysis of metabolic profiles in various tissues led to the identification of the N-oxides as major metabolites. The successful inhibition and redirection of metabolism away from the indole acids towards the parent compounds and their structurally unique metabolites were demonstrated in animals pretreated with iproniazid.
Citations in the library
Cited by 50
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- Clinical toxicology of newer recreational drugs Clinical Toxicology October 1, 2011
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Recreational Use, Analysis and Toxicity of Tryptamines Current Neuropharmacology December 10, 2014
and 45 more in the library
Cites 5
- The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine American Journal of Psychiatry February 1, 1976
- Hallucinogenic N-methylated indolealkylamines in the cerebrospinal fluid of psychiatric and control populations. The British Journal of Psychiatry February 1, 1978
- Dimethyltryptamine levels in blood of schizophrenic patients and control subjects Psychopharmacology 1976
- Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography. Biochemical Pharmacology May 1, 1987
- Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), improniazid and chlorpromazine. Pharmacology, Biochemistry, and Behavior April 1978