In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat.
B R Sitaram, L Lockett, R Talomsin, G L Blackman, W R Mcleod
Biochemical Pharmacology May 1, 1987 DOI: 10.1016/0006-2952(87)90118-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vivo study Peer reviewed |
|---|---|
| Population | Animals |
| Intervention | iproniazid |
| Topics | 5-MeO-DMT DMT |
| Citations | 75 |
| Key points | N-oxides are major metabolites of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine, and iproniazid pretreatment redirects metabolism away from indole acids toward parent compounds and unique metabolites. |
Abstract
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N-demethylation, O-demethylation, and N-oxidation. The analysis of metabolic profiles in various tissues led to the identification of the N-oxides as major metabolites. The successful inhibition and redirection of metabolism away from the indole acids towards the parent compounds and their structurally unique metabolites were demonstrated in animals pretreated with iproniazid.