Default mode network components and its relationship with anomalous self-experiences in schizophrenia: A rs-fMRI exploratory study.
A. Roig-Herrero, Álvaro Planchuelo-Gómez, Marta Hernández-garcía, R. de Luis-García, Inés Fernández-Linsenbarth, Rosa Beño-ruiz de la Sierra, Vicente Molina
Psychiatry Research Neuroimaging May 1, 2022 DOI: 10.1016/j.pscychresns.2022.111495 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational neuroimaging study Peer reviewed |
|---|---|
| Sample size | 22 |
| Population | Patients with schizophrenia |
| Measures | Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) |
| Topics | Default mode network |
| Key findings | In 22 schizophrenia patients, IPASE scores correlated positively and significantly with intrahemispheric connectivity between the parahippocampal gyrus and the isthmus cingulate cortex in both hemispheres, and between the right parahippocampal gyrus and right rostral anterior cingulate cortex. The authors suggest this indicates a relation between hyperactive default mode network functional connectivity and the intensity of anomalous self-experiences, though they caution that larger samples and control comparisons are needed. |
Abstract
Anomalous self-experiences (ASEs) in schizophrenia have been under research for the last 20 years. However, no neuroimage studies have provided insight of the possible biological underpinning of ASEs. In this novel approach, the connectivity within the default mode network, calculated through a ROI-based analysis of functional magnetic resonance imaging data, was correlated to the ASEs scores assessed by the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) in a sample of 22 schizophrenia patients. The Pearson's correlation coefficients between IPASE scores and intrahemispheric connectivity of the parahippocampal gyrus with the isthmus cingulate cortex in both hemispheres, and right parahippocampal gyrus with the right rostral anterior cingulate cortex were positive and significant suggesting a relation between hyperactive functional connectivity and anomalous self-experiences intensity. Prior literature reported these areas to have a role in self-processing and consciousness as well as being anatomically connected. Further research with larger sample size and comparison with controls are needed to confirm the relationship of this connectivity with anomalous self-experiences.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cited by 5
- Towards a Neurophenomenological Understanding of Self-Disorder in Schizophrenia Spectrum Disorders: A Systematic Review and Synthesis of Anatomical, Physiological, and Neurocognitive Findings Brain Sciences May 23, 2023
- Cortical thickness of the posterior cingulate cortex is associated with the ketamine-induced altered sense of self: An ultra-high field MRI study. Journal of Psychiatric Research April 1, 2024
- Ipseity and Embodiment within the Lived Experience of Schizophrenia Theoría Revista del Colegio de Filosofía May 26, 2026
- Reliability and Validity of the Japanese Version of the Inventory of Psychotic-Like Anomalous Self-Experiences. International Journal of Methods in Psychiatric Research September 1, 2026
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health Biology April 1, 2025
Cites 7
- Self-disturbance and schizophrenia: structure, specificity, pathogenesis (Current issues, New directions). Schizophrenia Research 2014
- The minimal self hypothesis. Consciousness and Cognition October 1, 2020
- The Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE): Development and validation. Psychological Assessment January 2017
- Phenomenology and neurobiology of self disorder in schizophrenia: Primary factors. Schizophrenia Research December 2015
- Returning from oblivion: imaging the neural core of consciousness. Journal of Neuroscience April 4, 2012
and 2 more in the library