Introduction/Hypothesis: While many intensive care unit survivors report negative long-term psychological outcomes including post-traumatic stress disorder (PTSD), depression, and anxiety, some report a positive transformational outcome associated with the recall of a unique cognitive experience, often referred to using the poorly defined term of near-death experiences (NDE). This aspect of ICU...
These data show that alpha1 and beta3-adrenergic receptors may contribute to the mediation of MDMA-induced hyperthermia and that drugs targeting these receptors, such as carvedilol, warrant further investigation as novel therapies for the treatment of psychostimulant-induced hyperthermia and its sequelae.