Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model*
Jon E. Sprague, Petra Moze, David Caden, Daniel E. Rusyniak, Courtney Holmes, David S. Goldstein, Edward Mills
Critical Care Medicine June 1, 2005 DOI: 10.1097/01.ccm.0000165969.29002.70 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Hyperthermia Carvedilol Pharmacology Rhabdomyolysis Nadolol Catecholamine Adrenergic antagonist Rasagiline Hypothermia Anesthesia Citalopram Propranolol Endocrinology |
| Citations | 75 |
| Key points | Alpha1 and beta3-adrenergic receptors may contribute to MDMA-induced hyperthermia, and drugs targeting these receptors, such as carvedilol, warrant further investigation as treatments. |
Abstract
These data show that alpha1 and beta3-adrenergic receptors may contribute to the mediation of MDMA-induced hyperthermia and that drugs targeting these receptors, such as carvedilol, warrant further investigation as novel therapies for the treatment of psychostimulant-induced hyperthermia and its sequelae.