Psilocybin-Assisted Therapy for Trauma-Related Disorders: A Scoping Review of a Depression-Dominated Evidence Base with Implications for Intimate Partner Violence-Related PTSD
Mackenzie Hancock, Shambhu Prasad Adhikari, Nicole Getz
Open Science Framework 2025 DOI: 10.17605/osf.io/ar2s4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Scoping review Peer reviewed |
|---|---|
| Intervention | psilocybin-assisted therapy |
| Topics | Depression Psilocybin PTSD |
| Keywords | Domestic violence Posttraumatic stress Psychotherapist Clinical psychology Poison control Grey literature Systematic review Intimate partner Suicide prevention Clinical trial Injury prevention Medline Mental health Dsm-5 |
| Key findings | Psilocybin-assisted therapy has emerging evidence for treating trauma-related disorders, but research on its use for IPV survivors with brain injury is lacking and requires further clinical trials. |
Abstract
This scoping review examines the emerging evidence for psilocybin-assisted therapy (PAP) in treating trauma-related disorders such as posttraumatic stress disorder (PTSD), depression, and persistent post-concussion symptoms (PPCS), with specific implications for intimate partner violence (IPV)-related brain injury and PTSD. Guided by PRISMA-ScR methodology, we systematically searched Medline, Embase, CINAHL, PsycINFO, and grey literature from 2015–2025 to map existing research, identify gaps, and inform the design of future clinical trials of PaT for IPV survivors.