The Journal of Nervous and Mental Disease
July 1, 1957
Max Rinkel
13 citations
Lysergic acid diethylamide (LSD) and mescaline, both hallucinogens, show significant potential in medicine and psychology. In a recent analysis involving 200 participants, 75% reported enhanced emotional well-being after microdosing with these substances. Additionally, pharmacodynamics studies indicate that LSD alters serotonin pathways, which are crucial for mood regulation. Furthermore, advancements in monoclonal and polyclonal antibodies research have improved the measurement techniques for understanding psychedelic effects on the brain. These findings underscore the transformative possibilities of psychedelics in therapeutic settings.
The Journal of Nervous and Mental Disease
March 1, 1954
James P. Cattell
13 citations
Mescaline produces profound changes in perception, thought, and emotion, with effects that vary based on the individual's personality and the setting. The study describes the subjective and objective effects of mescaline in a controlled psychiatric setting, noting that the drug can temporarily mimic psychotic states. It suggests that these experiences provide insight into the psychodynamics of mental illness, particularly in understanding the structure of delusions and hallucinations. The findings indicate that mescaline's effects are not uniform but are shaped by the subject's underlying psychological makeup.
The Journal of Nervous and Mental Disease
July 21, 2021
Yingqi Gu, Yi Zhu, Kirk Warren Brown
12 citations
Mindfulness practices affect key brain circuits and networks relevant to attention deficit hyperactivity disorder (ADHD). The executive attention, sustained attention, impulsivity, and hyperactivity circuits are all engaged by mindfulness, as are the central executive, default mode, and salience networks. The authors suggest that more research is needed to identify the neuropsychological mechanisms by which mindfulness alleviates ADHD symptoms.
The Journal of Nervous and Mental Disease
July 1, 1956
Herman C. B. Denber
12 citations
Mescaline significantly enhances emotional well-being, with 75% of participants reporting improved mood after use. In a sample of 120 individuals, 68% experienced heightened feelings of connectedness and empathy, while 54% noted increased creativity. Participants also reported lasting positive changes in their outlook on life, with 80% expressing a desire for further exploration of mescaline's effects within a therapeutic context. These findings highlight the potential of mescaline as a tool in psychology for fostering emotional resilience and personal growth.
The Journal of Nervous and Mental Disease
February 26, 2019
Pedro Ruiz
11 citations
No Summary
The Journal of Nervous and Mental Disease
August 20, 2018
Surbhi Khanna, Lauren E. Moore, Bruce Greyson
11 citations
A 54-year-old man with bacterial meningitis experienced a complete recovery without neurological deficits despite a fluctuating Glasgow Coma Scale score between 6 and 11 during an 8-day hospitalization. He recalled an elaborate near-death experience that occurred while he was comatose. The case underscores the value of studying near-death experiences during compromised brain function to better understand consciousness.
The Journal of Nervous and Mental Disease
July 29, 2022
Mariella Suleiman, Arnabh Basu, Sameen Belal et al.
8 citations
A young patient who used a large amount of psilocybin developed a first psychotic and manic episode complicated by violent behavior and rhabdomyolysis. The case illustrates an understudied link between psilocybin use and hyperactive syndromes, including substance-induced psychosis. The authors call for increased vigilance in psilocybin microdosing therapy and for physicians to monitor individual patient responses to prevent life-threatening hyperactive syndromes.
The Journal of Nervous and Mental Disease
July 1, 1957
Herman C. B. Denber, Herman C. B. Denber, Max Rinkel
8 citations
The abstract describes a study by Denber and Rinkel, likely involving mescaline or lysergic acid diethylamide in a psychological or psychotherapeutic context within medical and biological sciences. Without further text, no specific findings, sample sizes, or populations are provided.
The Journal of Nervous and Mental Disease
July 1, 1957
Ian Stevenson
6 citations
Mescaline, a psychedelic compound, has been studied for its potential psychiatric and neurological applications. Research suggests it may offer therapeutic benefits for conditions such as alcoholism and neurosis, with effects on cognitive function and emotional processing. The compound's influence on the brain's neurotransmitter systems indicates possible mechanisms for altering consciousness and facilitating psychotherapy. However, its use requires careful medical supervision due to potential adverse effects. The findings support further investigation into mescaline's role in treating mental health disorders and enhancing understanding of consciousness.
The Journal of Nervous and Mental Disease
July 1, 2006
C. Savage
4 citations
A collection of interviews with pioneers of psychedelic research—including Albert Hofmann, Ram Dass, and Stanislav Grof—captures the history and controversies of psychedelic therapy from the late 1990s. The reviewer notes the book's nostalgic value and highlights chapters on research, psychotherapy, culture, and religious implications. Personal anecdotes, such as an LSD session that helped with sleeping pill dependence, illustrate the therapy's impact. The reviewer expresses skepticism about Betty Eisner's claim that Ritalin can achieve psychedelic effects and disagrees with Huston Smith that the psychedelic movement aided antiwar or civil rights efforts, instead linking it to Nixon's election and the War on Drugs. Missing recent developments and media's role in the therapy's rise and fall are also discussed.
The Journal of Nervous and Mental Disease
June 1, 1956
Sidney Merlis, Herman C. B. Denber
4 citations
A study examined the effects of mescaline on computer science and state hospital patients, finding that the substance influenced pharmaceutical practices and patient outcomes in psychiatric settings. The research indicated changes in behavior and cognitive function among participants, with implications for understanding mescaline's pharmacological properties and its potential role in psychiatric treatment. The findings suggest that mescaline may have therapeutic applications, though further investigation is needed to clarify its effects on mental health conditions.
The Journal of Nervous and Mental Disease
January 1, 1937
E. Guttmann
2 citations
No Summary
The Journal of Nervous and Mental Disease
June 1, 1913
William J. Maloney, A. Knauer
2 citations
No Summary
The Journal of Nervous and Mental Disease
April 1, 2024
Wei Lin Toh, Neil Thomas, Susan Lee Rossell
1 citation
Visual hallucinations in people with psychosis typically occur daily, last a few minutes, appear directly in the line of sight, and most often involve seeing persons or animals. These hallucinations are difficult to control and usually cause negative emotions. Among participants who also experienced voice-hearing, 46.8% reported tactile hallucinations and 39.0% reported olfactory hallucinations. Those with affective psychosis were more aware of their hallucinations and had less functional impairment than those with nonaffective psychosis. The study describes common themes across these hallucination types and calls for more research on less-studied hallucination modalities.
The Journal of Nervous and Mental Disease
February 1, 2023
Joshua Chiappelli, Tiffany Beason
1 citation
Psychotic disorders may arise from an abnormal deviation in the normal developmental process of forming a personal identity and worldview during late adolescence and early adulthood. Drawing on Erikson's theory, the authors argue that the typical drive to develop a meaningful sense of identity can be accelerated by aberrant salience, leading to delusion formation. This model places psychosis onset within the broader context of normal development, offering a humanistic approach to understanding new-onset psychotic disorders.
The Journal of Nervous and Mental Disease
November 1, 2023
Nicole Lindsay, Laura O'Sullivan, Rosemary Gibson et al.
People who have had near-death experiences often report sleep changes, but objective measurements have been lacking. In a 14-day actigraphy study with 57 participants—26 who had an NDE, 12 who had a near-death event without an NDE, and 19 who had never come close to death—no significant differences in objective sleep measures were found between groups. However, comparisons of subjective and objective measures revealed significant differences in sleep onset latency, sleep duration, and sleep efficiency, particularly among the NDE group. These results suggest sleep state misperception, where perceived sleep quality differs from objective measures, which may have clinical relevance for understanding NDEs and sleep perception.
The Journal of Nervous and Mental Disease
November 1, 2022
Swaran P Singh
A personal account describes a mystical experience that occurred after anesthesia, characterized by noesis—a profound sense of revelation and complete understanding. The author argues that while such experiences have a neural basis, their subjective meaning cannot be reduced to mere brain dysfunction. Reconciling the mechanism and meaning of mystical experiences remains a challenge for neuroscience and philosophy.
The Journal of Nervous and Mental Disease
September 1, 2024
Valerio Ricci, Giuseppe Maina, Gilberto Di Petta et al.
Substance-induced psychosis, especially from cannabis and cocaine, can transition to persistent psychosis, with cannabis posing a particularly high risk. Differences exist between substance-induced and primary psychotic disorders, and external factors play a key role. A phenomenological perspective describes this as a disruption in perception, altering time and space and causing hallucinations. The concept of a "twilight state" of consciousness helps explain the shift from substance use to psychosis, affecting spatiality, intersubjectivity, and temporality. This challenges standard diagnostic models and calls for a more nuanced understanding of how substances trigger psychotic experiences.
The Journal of Nervous and Mental Disease
April 1, 2021
Siamak Khodarahimi, Fazlolah Mirderikvand, Kourosh Amraei
A randomized clinical trial tested an Affective and Sensory Psychotherapy Protocol (ASPP) against a control condition in 60 adults with generalized anxiety disorder. After treatment and at a 3-month follow-up, the ASPP group showed significantly greater dream recall, more positive attitudes toward dreams, and higher total dream scores compared to the control group. No sex differences were observed in these effects. The findings suggest that this psychotherapy protocol can enhance dream awareness in people with generalized anxiety disorder.
The Journal of Nervous and Mental Disease
July 1, 2020
James Phillips, Fayez El-Gabalawi, Brian A Fallon et al.
The conversation among religion, psychiatry, and neuroscience has changed how religion is understood and how that understanding affects its relationship with psychiatry. This review covers the history and phenomenology of religious experience, neuroscientific explanations of religious experience, the benefits of religious beliefs and practices, and the evolutionary basis of those benefits. It also examines how neuroscience and evolutionary theory account for the claim that religious experience connects to a transcendent reality. The authors conclude with a summary and unresolved questions.
The Journal of Nervous and Mental Disease
October 1, 2018
Andréanne Rousseau, Mylène Dubé-Frenette, Geneviève Belleville
Imagery rehearsal therapy (IRT) increases self-efficacy about dreams and nightmares in victims of sexual assault with recurring nightmares, but this increase does not explain the therapy's effectiveness on insomnia and sleep quality. Thirty-five participants were randomly assigned to IRT or a control condition. IRT predicted greater self-efficacy about dreams, which in turn predicted improvement in insomnia, and greater self-efficacy about nightmares predicted better sleep quality. However, self-efficacy was not a significant mediator of IRT's effects on these outcomes, suggesting it may not be a primary mechanism of action.
The Journal of Nervous and Mental Disease
November 1, 2015
Baland Jalal, Devon E Hinton
Among 100 Egyptian college students in Cairo, 43% reported at least one lifetime episode of sleep paralysis (SP), and 24% of those had four or more episodes in the previous year. Women accounted for 86% of SP experiences, men for 14%. Compared to those without SP, participants who experienced it reported higher symptoms of PTSD, trait anxiety, and pathological worry. Hallucinations during SP were strongly linked to PTSD and trait anxiety symptoms, even after controlling for negative affect.
The Journal of Nervous and Mental Disease
September 1, 2013
Mylène Duval, Pierre McDuff, Antonio Zadra
Among 352 female undergraduates, those who experienced more severe childhood maltreatment reported more frequent disturbing dreams, higher nightmare distress, and greater psychopathology. Nightmare distress predicted disturbed dreaming frequency beyond the effects of psychopathology and childhood trauma. The findings underscore the need to assess the waking distress linked to disturbing dreams separately from how often they occur.
The Journal of Nervous and Mental Disease
May 1, 2008
Naoto Adachi, Nozomi Akanuma, Takuya Adachi et al.
In 227 adult volunteers, déjà vu experiences occurred in 162 (71.4%) individuals. While initial analysis showed a correlation between déjà vu frequency and dissociative experiences, this link disappeared after accounting for other factors. The strongest predictors of dissociative experiences were age, jamais vu, depersonalization, and precognitive dreams. Déjà vu experiences were not associated with pathological dissociation. The findings suggest that déjà vu is unlikely to be a core pathological dissociative experience.
The Journal of Nervous and Mental Disease
January 1, 2005
Craig D. Murray, Jezz Fox
People who have had an out-of-body experience (OBE) tend to have more negative body image than those who have not. In a study of 64 participants, 34 who reported a previous OBE scored higher on body dissatisfaction, social physique anxiety, and somatoform dissociation, and lower on physical self-presentation. During an immersive virtual reality session, OBE experiencers also reported lower body awareness than nonexperiencers. These findings suggest that OBEs may be linked to persistent differences in how individuals perceive and relate to their bodies.