Design and synthesis of natural product-based ligands with high affinity to the kappa-opioid receptor
Planta Medica August 1, 2011 JK Zjawiony, PR Polepally, B.l. Roth et al. 10 citations
Psychoactive natural products play an important role in the discovery and development of new drugs for the treatment of central nervous system (CNS) disorders. Our studies are focusing on identification of plant metabolites responsible for CNS activity and designing new ligands with high affinity to CNS receptors. Salvinorin A, the most potent naturally occurring hallucinogen isolated from the...