Biotransformation of Tryptamine in Fruiting Mycelia ofPsilocybe cubensis
Planta Medica June 1, 1989 DOI: 10.1055/s-2006-961995 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Mycelial cultures of Psilocybe cubensis |
| Topics | Psilocybin |
| Keywords | Tryptamine Mycelium Biotransformation Chromatography Botany Stereochemistry |
| Citations | 13 |
| Key points | Feeding tryptamine to Psilocybe cubensis mycelial cultures yields fruit bodies with psilocin levels up to 3.3% dry mass, the highest described in any mushroom. |
Abstract
Mycelial cultures of PSILOCYBE CUBENSIS, with the ability to form psilocybin and psilocin DE-NOVO, also hydroxylated and methylated fed tryptamine to give psilocin in up to 3.3% dry mass of the obtained fruit bodies. By using HPLC and TLC, it was found that these mushrooms contain only a small amount of psilocybin (0.01-0.2% dry mass). The values of psilocin are the highest described in any mushrooms.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |
Citations in the library
Cited by 8
- Extraction and analysis of indole derivatives from fungal biomass Journal of Basic Microbiology 1994
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond Biotechnology Advances August 31, 2023
- Occurrence of psilocybin and psilocin in Psilocybe pseudobullacea (Petch) Pegler from the Venezuelan Andes Journal of Ethnopharmacology July 1, 1994
- “The mushroom was more alive and vibrant”: Patient reports of synthetic versus organic forms of psilocybin Journal of Psychedelic Studies October 29, 2024
and 3 more in the library