Despite decades of neuroscience research and significant investment in addiction neuroimaging, clinical outcomes for individuals with substance use and behavioural addictions remain poor. Only 1.8% of people with substance use disorders receive effective treatment, highlighting a major disconnect between mechanistic understanding and clinical utility. This paper calls for a reorientation of...
Clinical and preclinical studies increasingly support the antidepressant potential of several anesthetic agents, including ketamine, propofol, nitrous oxide (N2O), sevoflurane, and isoflurane. Their therapeutic effects appear to arise from the regulation of multiple interconnected systems: modulation of glutamatergic and GABAergic signaling, interaction with monoaminergic neurotransmitters...
To investigate the current status and determinants of self-transcendence in gastric cancer patients undergoing chemotherapy and to establish a foundation for clinical development of interventions. A convenience sampling method was employed to select 507 gastric cancer patients undergoing chemotherapy in the oncology department of a tertiary hospital in Wuxi City, Jiangsu Province, from October...
Nurses working in Neonatal and Pediatric Intensive Care Units (NICU/PICU) experience high levels of stress that can diminish emotional resilience and job engagement. Mindfulness-based interventions (MBIs) are known to enhance psychological well-being; however, evidence in culturally diverse settings, such as Saudi Arabia and Egypt, remains limited. This study assessed the effects of mindfulness...
Substantial evidence demonstrates that the brain is more interested in faces than in other subjects and that self-related material, particularly self-images, have higher saliency than non-self-referential material. Studies of self-portraits have revealed correlations between stylistic elements and artists' states of mind. Edvard Munch, a founder of Expressionism and most famous for "The...
This study aimed to evaluate the effectiveness of a short video app-guided mindfulness meditation intervention in improving psychological flexibility and self-compassion and reducing rumination and depressive symptoms among failed entrepreneurs. A randomized controlled trial was conducted with 100 recently failed entrepreneurs (aged 25-55), who were randomly assigned to either an intervention...
Frontiers in Psychiatry2025Rebecca Paetow, Maike Franziska Dohrn, Michelle Finner-Prével et al.
Nitrous oxide (N2O) is used for anesthetic purposes but has gained popularity as a recreational substance. Despite its potentially severe adverse effects, knowledge about N2O use within psychiatric populations is limited. This study aimed to evaluate the life-time prevalence and patterns of N2O consumption among patients with psychiatric disorders. A retrospective observational cohort study was...
To investigate the current status of illness perception, hope levels, coping styles, and self-transcendence among gastric cancer patients undergoing chemotherapy, and to explore the chain-mediating role of hope levels and coping styles in illness perception and self-transcendence. This study is a cross-sectional study. A convenience sampling method was used to select 507 gastric cancer patients...
Meditation combined with antipsychotic medication can effectively improve the clinical symptoms and prognosis of patients with schizophrenia, but its underlying neural circuit mechanism is not clear. Many previous studies have shown that the symptoms of schizophrenia are related to dysfunction of the insula. We aimed to explore the neural circuitry mechanisms associated with insular dynamic...
To systematically evaluate the impact of mindfulness-based interventions on insight and stigma in patients with schizophrenia. Randomized controlled trials (RCTs) and quasi-randomized controlled trials investigating the effects of mindfulness-based interventions on insight and stigma in schizophrenia patients were retrieved from databases including CNKI, Wanfang, VIP, CBM, PubMed, Cochrane...
This review systematically assessed the evidence on the effectiveness and safety of prāṇāyāma, traditional yogic breathing techniques, for patients diagnosed with mental disorders. We searched PubMed, PsycINFO, and Central until April 2024. We calculated standardized mean differences (SMDs) with 95% confidence intervals (CIs) from both intention-to-treat (ITT) and per-protocol (PP) data for...
Problematic Social Media Use (PSMU) refers to an individual's long-term, high-intensity use of social media. Although this behavior is not pathological, it has a negative impact on the physical and mental health of individuals. In the past, intervention methods used for PSMU often controlled behavior to reduce the usage time of individual social media platforms. However, because psychological...
Methamphetamine (MA) dependence leads to severe physical and psychological issues. Current treatments, including psychosocial therapies and residential rehabilitation, face limitations such as high relapse rates, cost, and accessibility issues. As a result, there is an urgent need for novel approaches to treat MA dependence that are effective, affordable, and accessible to patients. Psilocybin,...
The "wine of jurema", used in ancient Brazilian shamanic rituals, is rich in N,N-dimethyltryptamine (DMT), a naturally occurring tryptamine like serotonin and melatonin. Widely found in plants and animals, DMT is the main component of some botanical tisanes used for centuries as a channel of communication with the otherworld (1, 2). Despite being classified as a "classical psychedelic” (2-4),...
Frontiers in PsychiatryOctober 30, 2024Jisu Park, Taejung Kim, Han-Tsung Min et al.4 citations
Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin, highlighting its chemical properties, mechanisms of action, and burgeoning role in psychiatric treatment. Furthermore, we examined the clinical applications and potential therapeutic benefits of psilocybin...
Objective: Bad dreams and nightmares can have a strong psychological impact. However, although the scientific literature points in the direction of an established association between nightmares and psychopathology, many of the studies investigating these links have been carried out on a general population. This systematic literature review aimed to identify studies that have used a sample from...
Debates concerning the reliability and validity of operationalized criteria and diagnostic tools have surrounded the issue of schizophrenia diagnosis and clinical decision-making related to the disorder. The notion of the praecox feeling (PF) has played a prominent role in the discussions as an example of the possibility of a rapid and potentially valid diagnosis based solely on “intuition” or...
Objectives The purpose of this systematic review of randomized controlled trials (RCTs) was to evaluate the effectiveness, safety, and tolerability of psilocybin in adult patients with major depressive disorder (MDD). Methods A systematic search (up to September 14, 2023) was conducted for RCTs that examined the efficacy, safety, and tolerability of psilocybin in physically healthy adult...
protocols are designed to integrate and harness the full range of ketamine's intrinsic properties, ketamine therapies can realize their full potentials [3], possibly leading to improved outcomes in broader patient populations. Our first paper, "The Montreal model: An integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression," takes this path toward...
Objective Psilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the association of psychological protocols with the efficacy of psilocybin-assisted therapy for depressive symptoms. Method Five major databases were systemic searched for...
Psilocybin has reemerged as a promising treatment for difficult-to-treat depression (DTD). Although there is limited evidence regarding interactions between psilocybin and other psychotropic drugs, clinical trials require that patients discontinue their antidepressants before study entry to isolate the benefits of psilocybin and to minimize the risk of adverse events. We present the first case...
Background Hypertension is a major source of morbidity and mortality worldwide, particularly for racial and ethnic minorities who face higher rates of hypertension and worse health-related outcomes. Recent research has reported on protective associations between classic psychedelics and hypertension; however, there is a need to explore how race and ethnicity may moderate such associations....
Resistance to traditional treatment methods is still a major obstacle in modern psychiatry. As a result, several studies are currently being conducted to find effective alternatives to traditional therapies. One of these alternatives is psilocybin, a psychedelic substance that has been tested in clinical trials as an adjunct to psychotherapy. These studies focus on patients with major...