Frontiers in Psychiatry - The Consciousness Library

Short-term safety and tolerability profile of 5-methoxy-N,N-dimethyltryptamine in human subjects: a systematic review of clinical trials.

Frontiers in Psychiatry 2024 Aleksander Kwaśny, Alina Wilkowska, Wiesław Jerzy Cubała 10 citations

Psychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel rapid-acting antidepressant. In this systematic review, we analyze the safety and tolerability evidence from clinical trials. Following the Preferred...

DOI: 10.3389/fpsyt.2024.1477996 Full text 5-MEO-DMT Psychedelics entheogens Hallucinogens Tolerability +6

Major challenges in youth psychopathology: treatment-resistant depression. A narrative review.

Frontiers in Psychiatry 2024 Giulia Menculini, Gianmarco Cinesi, Francesca Scopetta et al. 10 citations

Major depressive disorder (MDD) represents a major health issue in adolescents and young adults, leading to high levels of disability and profoundly impacting overall functioning. The clinical presentation of MDD in this vulnerable age group may slightly differ from what can be observed in adult populations, and psychopharmacological strategies do not always lead to optimal response. Resistance...

DOI: 10.3389/fpsyt.2024.1417977 Full text Esketamine Major depressive disorder Adolescents Fast-acting antidepressants +5

Long-term benefits to psychological health and well-being after ceremonial use of Ayahuasca in Middle Eastern and North African immigrants and refugees.

Frontiers in Psychiatry 2024 Matthew X. Lowe, Hannes Kettner, Del R. P. Jolly et al. 9 citations

Refugees and immigrants can experience complex stressors from the process of immigration that can have lasting and severe long-term mental health consequences. Experiences after ayahuasca ingestion are shown to produce positive effects on psychological wellbeing and mental health, including anecdotal reports of improved symptoms of trauma and related disorders. However, data on the longitudinal...

DOI: 10.3389/fpsyt.2024.1279887 Full text Ayahuasca Immigrant Longitudinal Naturalistic +5

Mindfulness, social evaluation anxiety, and self-regulation: exploring their association on impulsive behavior among athletes.

Frontiers in Psychiatry 2024 Zhangyi Zhong, Hongyu Jiang, Huilin Wang et al. 9 citations

Athletes, due to frequent physical interactions in competitive sports, are prone to impulsive behavior. Impulsive behavior is a prevalent psychological factor in sports, often leading to performance-affecting errors. This cross-sectional survey investigated the relationship between mindfulness and athletes' impulsive behavior. We sampled 403 athletes from youth training centers, universities,...

DOI: 10.3389/fpsyt.2024.1404680 Full text Mindfulness Athletes Impulsive behavior Self-regulation +1

Effects of esketamine and fluoxetine on depression-like behaviors in chronic variable stress: a role of plasma inflammatory factors.

Frontiers in Psychiatry 2024 Haixia Chen, Xinxin Zhao, Xinxu Ma et al. 9 citations

Mounting evidence has identified the rapid and sustained antidepressive and anxiolytic-like effects of esketamine. However, the underlying mechanism of this no-monoamine target rapid-onset antidepressant is still underexplored. Immune-inflammatory pathways and cell-mediated immune activation, mainly including inflammatory cytokines in plasma, play a pivotal role in the pathogenesis of major...

DOI: 10.3389/fpsyt.2024.1388946 Full text Esketamine Major depressive disorder Chronic variable stress Fluoxetine +6

A novel framework for ketamine-assisted couple therapy.

Frontiers in Psychiatry 2024 Chandra Khalifian, K Rashkovsky, E Mitchell et al. 8 citations

Intimate relationship distress is prevalent and is associated with poorer health, mental health, and mortality outcomes. Evidence-based couple therapies target cognitive, behavioral, and emotional processes that underlie relationship dysfunction. Increasing research and clinical evidence supports the efficacy of ketamine-assisted psychotherapy (KAP) for addressing clinical mental health...

DOI: 10.3389/fpsyt.2024.1376646 Full text Psychedelic therapy Couple therapies Ketamine-assisted psychotherapy Psychedelic therapies +6

Anhedonia and depression severity measures during ketamine administration in treatment-resistant depression.

Frontiers in Psychiatry 2024 Aleksander Kwaśny, Wiesław Jerzy Cubała, Adam Włodarczyk 7 citations

Anhedonia is a core symptom of depression characterized by a diminished ability to experience pleasure. Currently available treatments for depression often fall short in adequately addressing anhedonia that often presents as a chronic and debilitating symptom. Ketamine is known to possess antianhedonic properties. This post-hoc analysis of a naturalistic observational study of...

DOI: 10.3389/fpsyt.2024.1334293 Full text Major depressive disorder Treatment-resistant depression Ketamine therapy Anhedonia symptoms +2

Baseline monocyte count predicts symptom improvement during intravenous ketamine therapy in treatment-resistant depression: a single-arm open-label observational study.

Frontiers in Psychiatry 2024 Bruno Pedraz-Petrozzi, Moritz Spangemacher, Anton Deicher et al. 6 citations

Neuroinflammatory processes in depression are associated with treatment resistance to conventional antidepressants. Ketamine is an effective new therapeutic option for treatment-resistant depression (TRD). Its well-established immunomodulatory properties are hypothesized to mediate its antidepressant effect. In this context, higher levels of inflammation may predict a better treatment response....

DOI: 10.3389/fpsyt.2024.1415505 Full text Treatment-resistant depression Immunity Inflammation Monocyte +7

Attitudes of European psychiatrists on psychedelics: a qualitative study.

Frontiers in Psychiatry 2024 Marija Franka Žuljević, Nando Breški, Mariano Kaliterna et al. 6 citations

It is important to understand how mental health practitioners view recent findings on psychedelic-assisted psychotherapy (PAP) as there is potential this treatment may be incorporated into clinical practice. The aim of our study was to explore how psychiatrists who are not involved in psychedelic research and who are located in the European region perceive psychedelics and PAP. We conducted...

DOI: 10.3389/fpsyt.2024.1411234 Full text MDMA Psilocybin Psychedelic therapy Psychedelics +5

Psychiatric and legal considerations for ketamine treatment within prison settings.

Frontiers in Psychiatry 2024 Michael Bayrhammer-Savel, Martin Ortner, Marie Claire Van Hout et al. 6 citations

The fundamental right to equivalence of health care in prison settings encompasses the provision of medication to address mental health conditions. Considering the increased risk for self-harm among individuals dealing with depression, the limited effectiveness of conservative antidepressants is a major challenge in psychiatry. The high prevalence of suicidal tendencies within prison...

DOI: 10.3389/fpsyt.2024.1316108 Full text Treatment-resistant depression Human rights Suicidality Treatment resistant depression +3

Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst?

Frontiers in Psychiatry 2024 Magdalena Więdłocha, Piotr Marcinowicz, Jan Komarnicki et al. 4 citations

Borderline personality disorder (BPD) is diagnosed in 10-30% of patients with major depressive disorder (MDD), and the frequency of MDD among individuals with BPD reaches over 80%. The comorbidity of MDD and BPD is associated with more severe depressive symptoms and functional impairment, higher risk of treatment resistance and increased suicidality. The effectiveness of ketamine usage in...

DOI: 10.3389/fpsyt.2024.1398859 Full text Esketamine Major depressive disorder Mdd Borderline personality disorder +7

From antidepressants and psychotherapy to oxytocin, vagus nerve stimulation, ketamine and psychedelics: how established and novel treatments can improve social functioning in major depression.

Frontiers in Psychiatry 2024 Aleksandra Kupferberg, Gregor Hasler 4 citations

Social cognitive deficits and social behavior impairments are common in major depressive disorder (MDD) and affect the quality of life and recovery of patients. This review summarizes the impact of standard and novel treatments on social functioning in MDD and highlights the potential of combining different approaches to enhance their effectiveness. Standard treatments, such as antidepressants,...

DOI: 10.3389/fpsyt.2024.1372650 Full text Ketamine Major depressive disorder Antidepressants Impairments +7

Evaluation of easy-to-implement anti-stress interventions in a series of N-of-1 trials: study protocol of the anti-stress intervention among physicians study.

Frontiers in Psychiatry 2024 Valentin Max Vetter, Tobias Kurth, Stefan Konigorski 4 citations

Adverse effects of chronically high levels of stress on physical and mental health are well established. In physicians, the effects of elevated stress levels exceed the individual level and include treatment errors and reduced quality of patient-doctor relationships. Breathing and mindfulness-based exercises have been shown to reduce stress and could serve as an immediate and easy-to-implement...

DOI: 10.3389/fpsyt.2024.1420097 Full text Breathwork Mindfulness N-of-1 trial Anti-stress intervention +3

Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol.

Frontiers in Psychiatry 2024 Pablo Sabucedo, Óscar Andión, Robert A Neimeyer et al. 4 citations

Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased attention over the past decades. Evidence-based approaches to prevent PGD are currently scarce, and not always effective. This paper introduces a protocol for a clinical trial exploring the effectiveness of a Meaning Reconstruction psychotherapy...

DOI: 10.3389/fpsyt.2024.1484736 Full text Ayahuasca Psychedelic-assisted therapy Bereavement Meaning reconstruction +9

Case report: Adult with bipolar disorder and autism treated with ketamine assisted psychotherapy.

Frontiers in Psychiatry 2024 Christopher P Harris, Becky Jones, Kathryn Walker et al. 4 citations

Evidence has increased in recent years regarding the potential for ketamine to serve as a novel treatment option for a range of conditions, particularly depression (unipolar and bipolar). However, research regarding ketamine as a potential therapeutic for Autism Spectrum Disorder (ASD) is lacking, despite high overlap with bipolar depression and theoretical foundations for its use. A...

DOI: 10.3389/fpsyt.2024.1322679 Full text Autism spectrum disorder Bipolar disorder Case report Ketamine assisted psychotherapy +6

Case report: two cases of rhabdomyolysis following esketamine treatment.

Frontiers in Psychiatry 2024 René Zeiss, Melissa Schweizer, Bernhard J. Connemann et al. 3 citations

Major depressive disorder is a mental disorder affecting millions of people worldwide. A considerable proportion of patients demonstrate a lack of response to conventional treatment. With the recent introduction of esketamine, a new treatment option has been approved for treatment-resistant depression. Although the medication is efficacious in a substantial portion of cases, rare, but possibly...

DOI: 10.3389/fpsyt.2024.1450092 Full text Treatment-resistant depression S-ketamine Adr Adverse drug reaction +7

Mindfulness-based relapse prevention targeting psychological craving and trait mindfulness in young Chinese women with methamphetamine dependence: a randomized controlled trial.

Frontiers in Psychiatry 2024 Xuan Liu, Yidan Zhang, Hongxin Cheng et al. 3 citations

We recruited 58 MA-dependent young adult females from a compulsory isolation drug rehabilitation center in Sichuan Province and randomly divided them into an MBRP group (n = 29) and a control group (n = 29) according to their degree of psychological craving. The MBRP group received 2 hours of MBRP training twice a week for 4 weeks, alongside routine treatment at the drug rehabilitation center....

DOI: 10.3389/fpsyt.2024.1339517 Full text Ma-dependent Mbrp Female Psychological craving +1

The dynamic strategy shifting task: Optimisation of an operant task for assessing cognitive flexibility in rats.

Frontiers in Psychiatry 2024 Jonathan Martin Flintoff, Suzy Alexander, James Paul Kesby et al. 3 citations

Although schizophrenia is associated with a broad range of symptoms including hallucinations, delusions, and reduced motivation, measures of cognitive dysfunction, including cognitive flexibility and executive function, are the strongest predictors of functional outcomes. Antipsychotic medications are useful for reducing psychotic symptoms, but they are ineffective at improving cognitive...

DOI: 10.3389/fpsyt.2024.1303728 Full text Cognitive flexibility Neuropsychiatric disease Operant tasks Strategy-shifting +5

A qualitative investigation of the Montgomery-Åsberg depression rating scale: discrepancies in rater perceptions and data trends in remote assessments of rapid-acting antidepressants in treatment resistant depression.

Frontiers in Psychiatry 2024 Gianna Capodilupo, Raymond Blattner, Anita Must et al. 3 citations

Despite the development of many successful pharmaceutical interventions, a significant subset of patients experience treatment-resistant depression (TRD). Ketamine and its derivatives constitute a novel therapeutic approach to treat TRD; however, standard tools, such as the Montgomery-Åsberg Depression Rating Scale (MADRS) are still being used to measure symptoms and track changes. The aim of...

DOI: 10.3389/fpsyt.2024.1289630 Full text Rapid acting antidepressants Rater perception Depression treatment Clinical assessment scales +3

Impact of minimal self disorders on naturalistic episodic memory in first-episode psychosis and parallels in healthy individuals with schizotypal traits.

Frontiers in Psychiatry 2024 Delphine Yeh, Sylvain Penaud, Alexandre Gaston-Bellegarde et al. 3 citations

Self-disorders constitute a core feature of the schizophrenia spectrum, including early stages such as first-episode psychosis (FEP). These disorders impact the minimal Self, or bodily self-consciousness, which refers to the basic, pre-reflective sense of embodied experience. The minimal Self is intrinsically linked to episodic memory, which captures specific past experiences of the Self....

DOI: 10.3389/fpsyt.2024.1469390 Full text Autobiographical memory Bodily self-consciousness Embodiment Episodic memory +4

Empowering understanding: navigating consent to ketamine treatment in adolescent mental health.

Frontiers in Psychiatry 2024 Aakash Sathappan, Benjamin Yudkoff 3 citations

The rising prevalence of mental health disorders in adolescents, compounded by treatment resistance, underscores the need for innovative interventions. Ketamine, recognized for its rapid antidepressant and anti-suicidal effects in adults, has recently emerged as a potential treatment for adolescents with treatment-resistant depression and suicidality. This paper aims to highlight key elements...

DOI: 10.3389/fpsyt.2024.1433348 Full text Informed consent Ketamine therapy Adolescent mental health Medical ethics +1

Estimating the benefit of esketamine nasal spray versus real-world treatment on patient-reported functional remission: results from the ICEBERG study.

Frontiers in Psychiatry 2024 Albino J Oliveira-Maia, Benoit Rive, Yordan Godinov et al. 3 citations

Treatment resistant depression (TRD) affects approximately 10-30% of patients with major depressive disorder, and most patients with TRD do not respond to real-world treatments (RWT). Treatment with esketamine nasal spray (NS) plus a selective serotonin or serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) has significant long-term clinical benefit over RWT in patients with TRD. However,...

DOI: 10.3389/fpsyt.2024.1459633 Full text Esketamine nasal spray Sheehan disability scale Functional remission Functioning +8

Effectiveness of mindfulness and Qigong training for self-healing in patients with Hwabyung and depressive disorder: a protocol for a randomized controlled trial.

Frontiers in Psychiatry 2024 Seok-In Yoon, Hui-Yeong Park, Hyun Woo Lee et al. 3 citations

Hwabyung is a Korean culture-bound syndrome characterized by anger-related physical and psychological symptoms. Depressive disorder is a common mental illness occurring worldwide, and has been reported to have a high comorbidity rate with Hwabyung. For patients with depressive disorders, differential diagnosis and combined treatment for Hwabyung should be considered. Mindfulness and Qigong may...

DOI: 10.3389/fpsyt.2024.1336656 Full text Depressive disorder Mindfulness Hwabyung Qigong +1

Dissociation and recovery in psychosis - an overview of the literature.

Frontiers in Psychiatry 2024 Claudia Calciu, Rob Macpherson, Sui Yung Chen et al. 2 citations

The relationship between dissociation and recovery from psychosis is a new topic, which could attract the interest of the researchers in the field of dissociation due to its relevance to their daily clinical practice. This review brings together a diversity of international research and theoretical views on the phenomenology of dissociation, psychosis and recovery and provides a synthesis by...

DOI: 10.3389/fpsyt.2024.1327783 Full text Dissociation Psychosis Recovery Rehabilitation +1

Hepatic injury and hepatic failure adverse events in 3,4-methylenedioxymethamphetamine users reported to the FDA Adverse Event Reporting System.

Frontiers in Psychiatry 2024 Tigran Makunts, Ruben Abagyan 2 citations

3,4-Methylenedioxymethamphetamine (MDMA) is being investigated in controlled clinical trials for use as an adjunct medication treatment for post-traumatic stress disorder. MDMA is metabolized by N-demethylation, primarily by CYP2D6, to its main inactive metabolite, 4-hydroxy-3-methoxymethamphetamine. It is also metabolized to a lesser extent by CYP1A2, CYP2B6, and CYP3A4 to its active...

DOI: 10.3389/fpsyt.2024.1414622 Full text Molly Ddi drug-drug interaction Faers MDMA 3,4-Methylenedioxymethamphetamine +5

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