IntroductionTwo serotonin reuptake inhibitors (SSRIs) have received FDA indication for treatment of PTSD, however the effectiveness of pharmacotherapy for PTSD is limited. Psychotherapy, including several well established evidence based methods, is the mainstay of PTSD treatment. Despite advances in this area, a significant percentage of PTSD patients are refractory to existing treatments....
European PsychiatryMarch 1, 2016Á. Palma Conesa, L. Galindo Guarín, M. Grifell Guàrdia et al.
Introduction New psychoactive substances (NPS) are substances that have recently appeared on the market and are not under international control. NPS use is experiencing an unprecedented increase. DiPT, 4-HO-DiPT and 4-AcO-DiPT are new psychoactive tryptamines and their effects may differ from those of other psychoactive tryptamines. Objective To explore the presence of DiPT, 4-HO-DiPT and...
Introduction: Sleep paralysis (SP) is relatively frequent condition, occurring either at sleep onset or sleep offset. It occurs at least once in a lifetime in 40–50% of normal subjects. During SP, the patient experiences gross motor paralysis, while the sensory system is clear. Hypnogogic and hypnopompic hallucinations are common. This experience might be interpreted as a spiritual phenomenon...
European PsychiatryMarch 1, 2016E. Silva, S. Simões, H. Espírito-Santo et al.
Introduction: Depression is one of the main causes of incapacity worldwide. Research has shown that mindfulness practice, self-compassion promotion, and spiritual well-being are beneficial for depressed individuals. Objective: Analyze the associations between compassion, mindfulness, and spiritual well-being, during and after a therapeutic intervention (concluded less than a year ago). Aims: To...
IntroductionNovel psychoactive substances (NPS) use is progressively increasing year on year. A new group of phenethylamines sold as legal stimulants and hallucinogens is being reported increasingly since 2012. Within this group, 25I-NBOMe is an outstanding substance with powerful effects and high affinity with the serotonin 2a (5HT2a) receptor. Several toxicity cases have been reported so...
IntroductionDespite recent findings pointing toward cannabis psychosis as one area where gender differences may exist, there has been a widespread lack of attention paid to gender as a determinant of health in both psychiatric services and within the field of addiction.ObjectivesTo explore gender differences in treatment presentations for people with cannabis psychosis.AimsTo use national data...
Les approches centrées sur l’autorégulation ainsi que sur l’acceptation des émotions et des sensations désagréables inspirées des programme MBSR et MBCT, représentent une voie intéressante dans la prise en charge des troubles du comportement alimentaire dans lesquels le contrôle et l’évitement sont au premier plan. Ces programmes permettent de travailler les aspects obsessionnels (comme les...
Abstract: Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent...
Social cognition is a crucial factor influencing development, progress, and treatment of psychiatric disorders. However, social cognition skills are insufficiently targeted by current treatment approaches. In particular, patients suffering from depression show an increased negative reaction to social exclusion and deficits in empathy. The 5HT-1A/2A receptor agonist psilocybin has previously...
In the online drug forum communities there are some 'educated and informed” users who can provide somehow reliable information on psychoactive compounds/combinations. These users, also called 'e-psychonauts”, may possess levels of technical knowledge relating to a range of ”novel psychoactive substances“ (NPS). Our project aimed at identifying and describing what available in terms of the...
Cortical 5HT2A receptors are largely expressed in layer 5 pyramidal neurons and appear to play a pivotal role in brain function in that they gate top-down descending inputs to local cortical microcircuits. There is evidence that they may play a role in depression in that the number of these receptors is increased in some people with depression and the augmenting action of atypical...
In this study we sought to explore patterns of neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia spectrum disorders (FES) and healthy controls (HC). Thirty-five FES patients and 35 age-, gender- and education-matched healthy controls. A task-related functional connectivity analysis with the use of independent component analysis (ICA). ICA...
European PsychiatryMarch 1, 2015A. Ghaffarinejad, H. Ziaadini, Siamak Zadeh et al.1 citation
Background Psychotic disorder due to industrial drug, such as methamphetamine addiction, is one of the important causes for referral to psychiatric hospital. Psychotic symptoms in these patients are varied. A group of researchers believe that methamphetamine-induced psychosis is completely similar to schizophrenia. Others believe that at least some cases of permanent psychotic clinical...
The consumption of cannabinoids has increased exponentially in the young. The cannabis-induced psychotic disorder is a rare condition, with transient paranoid ideation being the most common manifestation. Symptoms of anxiety are the most common adverse reaction associated with the moderate use of smoked cannabis. Cocaine use, in turn, is related to the appearance of delusions and hallucinations...
New title, or subtitle: „Current knowledge on the neurobiology of classical hallucinogens and their relevance for the treatment of mood and anxiety disorders‘ Hallucinogenic substances have been used for millenia. Still, the scientific investigation into the effects and mechanisms of classical hallucinogens in humans has only commenced with the discovery of LSD by Albert Hofmann in 1943. In the...
European PsychiatryMarch 1, 2015L. Orsolini, G. Papanti, F. Professor Schifano
Due to the growing demand for alternatives to arylcyclohexylamine-type substances, a new dissociative and hallucinogenic drug, Methoxphenidine (2-MXP; (±)-1-[1-(2-methoxyphenyl)-2-phenylethyl] piperidine; 2-Meo-diphenidine) has been recently appeared in the drug market. Very little information is still available in the scientific literature on this new compound. Recently, it was identified in...
Depuis 2008, une démarche de pleine conscience (MBCT) est proposée dans notre service (clinique des maladies mentales et de l’encéphale, centre hospitalier Sainte-Anne) à des patients souffrant de troubles bipolaires. Cette démarche en 8 séances a été adaptée spécifiquement à des patients bipolaires, en accord avec le Pr Segal (université de Toronto). Cent sept patients ont participé, entre...
European Psychiatry2014Pauline Monhonval, Christian Widakowich, Juan Martin Tecco
Recent theoretical and empirical work indicates renewed interest in the study of subjective experience in psychopathology (1,2). Phenomenological research shown that disturbance of the basic sense of self may be a core marker of the schizophrenia spectrum (3). This selfdisturbance occurs at the tacit, pre-reflective level of selfhood, where it exists a disruption of the sense of ownership of...
Nous avons mis en place dans notre CMP de secteur adulte, des protocoles de Mindfulness-Based Cognitive Therapy (MBCT) spécifiquement adaptés à des patients souffrant de phobie sociale. L’objectif de cette étude pilote était d’examiner l’efficacité du développement de MBCT à des patients souffrant de phobie sociale. Trente patients ont participé à ce jour à cette étude. Vingt-quatre personnes...
European Psychiatry2013V.M. Barrau-Alonso, J. Sendra-Lopez, N. Benítez-Álvarez et al.1 citation
Introduction Psychedelic drugs were used extensively in psychotherapy in the 1950s to lower psychological defences and facilitate emotional insight. Thousands of research participants were administered hallucinogens in the context of basic clinical research or therapeutic clinical research, resulting in hundreds of publications. Results across studies were ultimately inconclusive due to such...
Recent focus on early detection and intervention in psychosis has renewed interest in the psychopathological delineation and assessment of psychotic phenomena.These phenomena express a fundamental qualitative change of the patient's mentality (consciousness, subjectivity) which often surfaces already during the prodromal/at risk mental states and is typically manifested across several...
Introduction: There is a high prevalence of cannabis use among patients with psychosis. Persistent cannabis use in firstepisode psychosis affects prognosis and recovery. Understanding the reasons of cannabis use may help improve psychosis outcome. Several studies suggest that cannabis is used to ameliorate symptoms related to the disorder (self-medication hypothesis). Comparing the reasons of...
Introduction: Neurological soft signs (NSS) are minor or subtle neurological signs indicating non-specific cerebral dysfunction. They have been conceptualized as neurodevelopmental markers that mediate the biological propensity for the development of psychosis. Their interaction with the environmental factors such as cannabis use remains little studied. Objective: To study the relationship...
Introduction: The concept of person is connected to personality and self-transcendence belongs to its structure, as core component. The assessment of self-transcendence as part of human personality opens the gate of self-awareness in personology. Robert Cloninger is a distinctive researcher because he states that the comprehensive assessment of the human being includes the moral-spiritual...
This current study assessed neurocognitive functioning in a carefully selected sample of schizophrenia patients with and without heavy cannabis use and healthy controls. All subjects were negative for any other substance use. Schizophrenia subjects had impaired neurocognitive functions across a wide range of tasks compared to healthy controls. Cannabis using schizophrenia patients had focused...