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Altered attentional control strategies but spared executive functioning in chronic cannabis users.

Amy T Nusbaum, Paul Whitney, Carrie Cuttler, Alexander Spradlin, John M Hinson, Ryan J Mclaughlin

Drug and Alcohol Dependence December 1, 2017 DOI: 10.1016/j.drugalcdep.2017.09.019 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational study with experimental stress manipulation Peer reviewed
Sample size 79
Population 39 chronic cannabis users and 40 non-users
Topics Cannabis
Keywords Attentional control Cannabis use Cognitive flexibility Executive functions Stress
Key findings Cannabis users relied less on top-down attentional control than non-users in the no-stress condition, and stress and cannabis use interacted in predicting top-down attentional control. Despite this altered cognitive processing, cannabis users showed no overall performance deficits on executive function tasks.

Abstract

Cannabis use has increased rapidly in recent decades. The increase in cannabis use makes it important to understand the potential influence of chronic use on attentional control and other executive functions (EFs). Because cannabis is often used to reduce stress, and because stress can constrain attentional control and EFs, the primary goal of this study was to determine the joint effect of acute stress and chronic cannabis use on specific EFs. Thirty-nine cannabis users and 40 non-users were assigned to either a stress or no stress version of the Maastricht Acute Stress Test. Participants then completed two cognitive tasks that involve EFs: (1) task switching, and (2) a novel Flexible Attentional Control Task. These two tasks provided assessments of vigilant attention, inhibitory control, top-down attentional control, and cognitive flexibility. Salivary cortisol was assessed throughout the study. Reaction time indices showed an interaction between stress and cannabis use on top-down attentional control (p=0.036, np2=0.059). Follow-up tests showed that cannabis users relied less on top-down attentional control than did non-users in the no stress version. Despite not relying on top-down control, the cannabis users showed no overall performance deficits on the tasks. Chronic cannabis users performed cognitive tasks involving EFs as well as non-users while not employing cognitive control processes that are typical for such tasks. These results indicate alterations in cognitive processing in cannabis users, but such alterations do not necessarily lead to global performance deficits.

Comparable studies

Other experimental studies on cannabis, most cited first.

Study Year Design Participants
Smoked Cannabis' Psychomotor and Neurocognitive Effects in Occasional and Frequent Smokers Occasional (<2x/week) and frequent (≥4x/week) cannabis smokers 2015 Controlled within-subjects study n = 25
Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity Healthy volunteers experienced with cannabis but not regular users 2019 Within-subjects experimental design n = 17
Which biological and self-report measures of cannabis use predict cannabis dependency and acute psychotic-like effects? Young cannabis users 2018 Observational study (naturalistic, within-subject counterbalanced design) n = 410
Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects Healthy volunteers 2018 Experimental study n = 5
Coming off cannabis: a cognitive and magnetic resonance imaging study in patients with multiple sclerosis Patients with multiple sclerosis who began using cannabis after disease onset, used it... 2019 Quasi-experimental study with odd-even allocation n = 40

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