Accumulating evidence indicates the role of ketamine as a fast-onset antidepressant, with a rising controversy over its cognitive effect. This study aimed at investigating the short- and long-term cognitive and behavioral effects of chronic administration of ketamine, with an emphasis on hippocampal expression of the Trk B/Akt/mTOR signaling pathway in chronic mild stress (CMS)-exposed rats....
Accumulating evidence indicates the role of ketamine as a rapid-onset antidepressant, with a rising controversy regarding its cognitive and psychotic effects, especially with long-term use. However, no previous experimental study has directly compared short-term and long-term ketamine effects using a time schedule that simulates infusion protocols in major depressive disorder patients. This...
IntroductionPeganum harmala (Zygophyllaceae) is an herb native to the dry area of the Mediterranean east to northern India.The plant originated in Central Asia, but now grows wild in Africa, Middle East, India, South America, Mexico, and Southern USA [1].Seeds of Peganum harmala are growing widespread in Egypt.They are used as an anti-hemorrhoid and central nervous system (CNS) stimulating...