Accumulating evidence indicates the role of ketamine as a fast-onset antidepressant, with a rising controversy over its cognitive effect. This study aimed at investigating the short- and long-term cognitive and behavioral effects of chronic administration of ketamine, with an emphasis on hippocampal expression of the Trk B/Akt/mTOR signaling pathway in chronic mild stress (CMS)-exposed rats....
MDMA can cause life-threatening hyponatraemic encephalopathy when accompanied by excessive fluid ingestion. The mechanism involves inappropriate secretion of antidiuretic hormone.
We have previously shown that eating disorders are a compulsive behaviour disease, characterized by frequent recall of anorexic thoughts. Evidence suggests that memory is a neocortical neuronal network, excitation of which involves the hippocampus, with recall occurring by re-excitement of the same specific network. Excitement of the hippocampus by glutamate-NMDA receptors, leading to long-term...