Accumulating evidence indicates the role of ketamine as a fast-onset antidepressant, with a rising controversy over its cognitive effect. This study aimed at investigating the short- and long-term cognitive and behavioral effects of chronic administration of ketamine, with an emphasis on hippocampal expression of the Trk B/Akt/mTOR signaling pathway in chronic mild stress (CMS)-exposed rats....
Accumulating evidence indicates the role of ketamine as a rapid-onset antidepressant, with a rising controversy regarding its cognitive and psychotic effects, especially with long-term use. However, no previous experimental study has directly compared short-term and long-term ketamine effects using a time schedule that simulates infusion protocols in major depressive disorder patients. This...