Δ9-tetrahydrocannabinol (THC) is responsible for the intoxicating (psychotropic) effects of cannabis and cannabis-derived products currently available in the legal and illegal markets. The psychotropic effects of THC are produced via activation of CB1 cannabinoid receptors in the brain, which are normally engaged by endogenous cannabinoid (endocannabinoid) substances. Outside the brain, THC...
Introduction: Animal studies suggest that adolescent exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the intoxicating constituent of cannabis, causes lasting functional alterations in brain and other organs. Those studies often neglect the impact that age- and sex-dependent differences in the distribution and metabolism of the drug might exert on its pharmacological effects. Here, we provide a...