Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Female Mice.
Cannabis and Cannabinoid Research December 1, 2024 Alexa Torrens, Alex Mabou Tagne, Adren Tran et al.
Adolescent female mice given Δ9-THC had eight times higher peak plasma concentrations than adult females, but adult females had 25-50% higher brain concentrations and brain-to-plasma ratios. Metabolite levels were higher in plasma but lower in brain of adolescents compared to adults. These age-dependent differences in how the drug is distributed and metabolized may affect its pharmacological effects.