Psychopathology
August 18, 2025
Evan J. Kyzar, George H Denfield, Jasper Feyaerts et al.
1 citation
Dynamical systems theory (DST) has recently gained traction as a framework to describe and predict the progression of psychopathology. However, a number of challenges to the application of DST to psychopathology have arisen, including the heterogeneity of symptom measures and the lack of theoretical underpinnings to describe the temporal unfolding of psychiatric illnesses. In this article, we...
Journal of consciousness studies : controversies in science & the humanities
April 1, 2024
George H Denfield, Evan J. Kyzar
Philosophy of mind has made substantial progress on biologically-rooted approaches to understanding the mind and subjectivity through the enactivist perspective, but research on subjectivity within neuroscience has not kept apace. Indeed, we possess no principled means of relating experiential phenomena to neurophysiological processes. Here, we present the Nested States Model as a framework to...
Psychopathology
2024
George H Denfield, Evan J. Kyzar
1 citation
Subjective experience is central to the nature of mental illness, yet it has not played a central role in most empirical approaches to psychopathology. While phenomenological perspectives in psychiatry have seen a recent resurgence, there remains a need for more detailed models of psychopathological processes based on explicit phenomenological and enactive foundations. We present a framework...
October 16, 2023
George H Denfield, Evan J. Kyzar
preprint
Subjective experience is central to the nature of mental illness, yet it has not played a central role in most empirical approaches to psychopathology. Despite some recent progress, we lack detailed phenomenological models for psychopathological processes and mental disorders. Here, we present a framework through which such models could be constructed. This framework is derived from the Nested...
Molecular Psychiatry
2023
Evan J. Kyzar, George H Denfield
62 citations
Nearly all psychiatric diseases involve alterations in subjective, lived experience. The scientific study of the biological basis of mental illness has generally focused on objective measures and observable behaviors, limiting the potential for our understanding of brain mechanisms of disease states and possible treatments. However, applying methods designed principally to interpret objective...