The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders
Molecular Psychiatry October 3, 2017 Michelle Kokkinou, Abhishekh Hulegar Ashok, Oliver Howes 252 citations
Ketamine is a non-competitive antagonist at the N -methyl- d -aspartate receptor. It has recently been found to have antidepressant effects and is a drug of abuse, suggesting it may have dopaminergic effects. To examine the effect of ketamine on the dopamine systems, we carried out a systematic review and meta-analysis of dopamine measures in the rodent, human and primate brain following acute...