Objective This study investigated the macroscopic neural mechanisms of cognitive impairment after Deep Nuclei Intracerebral Hemorrhage (DNICH) from the dimensions of brain activity and brain networks, and further identified characteristic fingerprints of cognitive representation. Method Patients with cognitive impairment after DNICH and healthy controls (HC) were prospectively and consecutively...
The combination of bioinformatics and functional approaches was used to identify three cytochrome P450 from the CYP71 clan that perform the 19-hydroxylation of two monoterpene indole alkaloids (coronaridine and voacangine) from Voacanga thouarsii. Voacanga thouarsii is a medicinal plant from the Apocynaceae family producing monoterpene indole alkaloids (MIAs), notably iboga-type ones, to cope...
Interoceptive dysfunction represents a critical therapeutic target across multiple health domains. Contemporary interventions demonstrate limitations in efficacy and specificity, while traditional mind-body practices present empirically underexplored yet theoretically promising alternatives. This investigation systematically evaluates the psychophysiological effects of Hunyuan Zhuang, a Chinese...