Voacangine/coronaridine hydroxylases catalyze C19-hydroxylation in iboga alkaloid synthesis.
Planta March 23, 2026 Ana Luisa Lopez-Vazquez, Mickael Durand, Caroline Birer-Williams et al.
The combination of bioinformatics and functional approaches was used to identify three cytochrome P450 from the CYP71 clan that perform the 19-hydroxylation of two monoterpene indole alkaloids (coronaridine and voacangine) from Voacanga thouarsii. Voacanga thouarsii is a medicinal plant from the Apocynaceae family producing monoterpene indole alkaloids (MIAs), notably iboga-type ones, to cope...
DOI: 10.1007/s00425-026-04987-z (opens in new tab)
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Iboga
Voacanga thouarsii
C19-hydroxylation
Cytochrome p450
+3